| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C10orf71 | C15orf59 | ENSP00000363259 | ENSP00000457205 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | UPF0583 protein C15orf59; Chromosome 15 open reading frame 59 | 0.818 |
| C10orf71 | DALRD3 | ENSP00000363259 | ENSP00000344989 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3 | 0.630 |
| C10orf71 | DCAF7 | ENSP00000363259 | ENSP00000483236 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family | 0.820 |
| C10orf71 | DYRK1A | ENSP00000363259 | ENSP00000381932 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in t [...] | 0.873 |
| C10orf71 | DYRK1B | ENSP00000363259 | ENSP00000469863 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily | 0.823 |
| C10orf71 | FNTA | ENSP00000363259 | ENSP00000303423 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation | 0.686 |
| C10orf71 | FNTB | ENSP00000363259 | ENSP00000246166 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X | 0.704 |
| C10orf71 | KIAA1755 | ENSP00000363259 | ENSP00000279024 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | Uncharacterized protein KIAA1755; KIAA1755 | 0.589 |
| C10orf71 | SUDS3 | ENSP00000363259 | ENSP00000443988 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | Sin3 histone deacetylase corepressor complex component SDS3; Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes | 0.587 |
| C10orf71 | VSTM4 | ENSP00000363259 | ENSP00000331062 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | V-set and transmembrane domain-containing protein 4; Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors; V-set domain containing | 0.586 |
| C15orf59 | C10orf71 | ENSP00000457205 | ENSP00000363259 | UPF0583 protein C15orf59; Chromosome 15 open reading frame 59 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | 0.818 |
| C15orf59 | SUDS3 | ENSP00000457205 | ENSP00000443988 | UPF0583 protein C15orf59; Chromosome 15 open reading frame 59 | Sin3 histone deacetylase corepressor complex component SDS3; Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes | 0.586 |
| DALRD3 | C10orf71 | ENSP00000344989 | ENSP00000363259 | DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | 0.630 |
| DCAF7 | C10orf71 | ENSP00000483236 | ENSP00000363259 | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | 0.820 |
| DCAF7 | DYRK1A | ENSP00000483236 | ENSP00000381932 | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in t [...] | 0.983 |
| DCAF7 | DYRK1B | ENSP00000483236 | ENSP00000469863 | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily | 0.992 |
| DYRK1A | C10orf71 | ENSP00000381932 | ENSP00000363259 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in t [...] | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | 0.873 |
| DYRK1A | DCAF7 | ENSP00000381932 | ENSP00000483236 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in t [...] | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family | 0.983 |
| DYRK1A | FNTB | ENSP00000381932 | ENSP00000246166 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in t [...] | Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X | 0.565 |
| DYRK1B | C10orf71 | ENSP00000469863 | ENSP00000363259 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 | 0.823 |
