| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC12 | C6orf106 | ENSP00000288065 | ENSP00000363135 | Armadillo repeat containing 12 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | 0.714 |
| ARMC12 | SRPK1 | ENSP00000288065 | ENSP00000362931 | Armadillo repeat containing 12 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.682 |
| C17orf67 | C6orf106 | ENSP00000380959 | ENSP00000363135 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | 0.572 |
| C6orf1 | C6orf106 | ENSP00000417604 | ENSP00000363135 | Uncharacterized protein SMIM29; Chromosome 6 open reading frame 1 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | 0.531 |
| C6orf106 | ARMC12 | ENSP00000363135 | ENSP00000288065 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | Armadillo repeat containing 12 | 0.714 |
| C6orf106 | C17orf67 | ENSP00000363135 | ENSP00000380959 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67 | 0.572 |
| C6orf106 | C6orf1 | ENSP00000363135 | ENSP00000417604 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | Uncharacterized protein SMIM29; Chromosome 6 open reading frame 1 | 0.531 |
| C6orf106 | HSPBP1 | ENSP00000363135 | ENSP00000255631 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR; Armadillo-like helical domain containing | 0.734 |
| C6orf106 | PACSIN1 | ENSP00000363135 | ENSP00000484060 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching [...] | 0.758 |
| C6orf106 | RPS10 | ENSP00000363135 | ENSP00000481646 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | 40S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family | 0.662 |
| C6orf106 | SNRPC | ENSP00000363135 | ENSP00000244520 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | 0.535 |
| C6orf106 | SPDEF | ENSP00000363135 | ENSP00000363149 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | SAM pointed domain-containing Ets transcription factor; May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5’-GGAT- 3’ DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter; ETS transcription factor family | 0.576 |
| C6orf106 | SRPK1 | ENSP00000363135 | ENSP00000362931 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.524 |
| C6orf106 | UHRF1BP1 | ENSP00000363135 | ENSP00000192788 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | UHRF1-binding protein 1; May act as a negative regulator of cell growth | 0.585 |
| HSPBP1 | C6orf106 | ENSP00000255631 | ENSP00000363135 | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR; Armadillo-like helical domain containing | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | 0.734 |
| HSPBP1 | RPS10 | ENSP00000255631 | ENSP00000481646 | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR; Armadillo-like helical domain containing | 40S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family | 0.499 |
| PACSIN1 | C6orf106 | ENSP00000484060 | ENSP00000363135 | Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching [...] | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 | 0.758 |
| PACSIN1 | RPS10 | ENSP00000484060 | ENSP00000481646 | Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching [...] | 40S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family | 0.638 |
| PACSIN1 | SNRPC | ENSP00000484060 | ENSP00000244520 | Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching [...] | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | 0.474 |
| PACSIN1 | SPDEF | ENSP00000484060 | ENSP00000363149 | Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching [...] | SAM pointed domain-containing Ets transcription factor; May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5’-GGAT- 3’ DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter; ETS transcription factor family | 0.621 |
