| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP5J2 | ZNF76 | ENSP00000292475 | ENSP00000363064 | ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.705 |
| DSE | ZNF76 | ENSP00000332151 | ENSP00000363064 | Dermatan-sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.774 |
| ENOSF1 | ZNF76 | ENSP00000345974 | ENSP00000363064 | Mitochondrial enolase superfamily member 1; Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto- 3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.744 |
| FBXW7 | ZNF76 | ENSP00000281708 | ENSP00000363064 | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated [...] | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.657 |
| GRHL1 | ZNF76 | ENSP00000324693 | ENSP00000363064 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5’-AACCGGTT-3’. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.685 |
| MRPS11 | ZNF76 | ENSP00000317376 | ENSP00000363064 | Mitochondrial ribosomal protein S11 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.684 |
| TCP11 | ZNF76 | ENSP00000308708 | ENSP00000363064 | T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway; Belongs to the TCP11 family | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.932 |
| THAP11 | ZMAT5 | ENSP00000304689 | ENSP00000344241 | THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing | Zinc finger matrin-type 5; U11/U12 di-snRNP | 0.698 |
| THAP11 | ZNF76 | ENSP00000304689 | ENSP00000363064 | THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.794 |
| ZMAT5 | THAP11 | ENSP00000344241 | ENSP00000304689 | Zinc finger matrin-type 5; U11/U12 di-snRNP | THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing | 0.698 |
| ZMAT5 | ZNF76 | ENSP00000344241 | ENSP00000363064 | Zinc finger matrin-type 5; U11/U12 di-snRNP | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.809 |
| ZNF76 | ATP5J2 | ENSP00000363064 | ENSP00000292475 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] | 0.705 |
| ZNF76 | DSE | ENSP00000363064 | ENSP00000332151 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Dermatan-sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues | 0.774 |
| ZNF76 | ENOSF1 | ENSP00000363064 | ENSP00000345974 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Mitochondrial enolase superfamily member 1; Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto- 3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion | 0.744 |
| ZNF76 | FBXW7 | ENSP00000363064 | ENSP00000281708 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated [...] | 0.657 |
| ZNF76 | GRHL1 | ENSP00000363064 | ENSP00000324693 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5’-AACCGGTT-3’. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed | 0.685 |
| ZNF76 | MRPS11 | ENSP00000363064 | ENSP00000317376 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Mitochondrial ribosomal protein S11 | 0.684 |
| ZNF76 | TCP11 | ENSP00000363064 | ENSP00000308708 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway; Belongs to the TCP11 family | 0.932 |
| ZNF76 | THAP11 | ENSP00000363064 | ENSP00000304689 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing | 0.794 |
| ZNF76 | ZMAT5 | ENSP00000363064 | ENSP00000344241 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger matrin-type 5; U11/U12 di-snRNP | 0.809 |
