node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HSP90AA1 | ITGB1BP2 | ENSP00000335153 | ENSP00000362935 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | 0.660 |
HSP90AA1 | PPP5C | ENSP00000335153 | ENSP00000012443 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Pa [...] | 0.988 |
HSP90AA1 | PPP5D1 | ENSP00000335153 | ENSP00000471730 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Protein PPP5D1; PPP5 tetratricopeptide repeat domain containing 1 | 0.557 |
HSP90AA1 | SUGT1 | ENSP00000335153 | ENSP00000367208 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Protein SGT1 homolog; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins | 0.998 |
IQGAP1 | ITGB1BP2 | ENSP00000268182 | ENSP00000362935 | Ras GTPase-activating-like protein IQGAP1; Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | 0.623 |
ITGB1 | ITGB1BP2 | ENSP00000379350 | ENSP00000362935 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | 0.613 |
ITGB1BP2 | HSP90AA1 | ENSP00000362935 | ENSP00000335153 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.660 |
ITGB1BP2 | IQGAP1 | ENSP00000362935 | ENSP00000268182 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Ras GTPase-activating-like protein IQGAP1; Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth | 0.623 |
ITGB1BP2 | ITGB1 | ENSP00000362935 | ENSP00000379350 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.613 |
ITGB1BP2 | PDHA1 | ENSP00000362935 | ENSP00000369134 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.661 |
ITGB1BP2 | PDK3 | ENSP00000362935 | ENSP00000387536 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species | 0.808 |
ITGB1BP2 | PPP5C | ENSP00000362935 | ENSP00000012443 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Pa [...] | 0.684 |
ITGB1BP2 | PPP5D1 | ENSP00000362935 | ENSP00000471730 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Protein PPP5D1; PPP5 tetratricopeptide repeat domain containing 1 | 0.684 |
ITGB1BP2 | SMPX | ENSP00000362935 | ENSP00000368808 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Deafness associated genes | 0.800 |
ITGB1BP2 | SUGT1 | ENSP00000362935 | ENSP00000367208 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Protein SGT1 homolog; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins | 0.894 |
ITGB1BP2 | SYNC | ENSP00000362935 | ENSP00000386439 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins | 0.668 |
PDHA1 | ITGB1BP2 | ENSP00000369134 | ENSP00000362935 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | 0.661 |
PDHA1 | PDK3 | ENSP00000369134 | ENSP00000387536 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species | 0.997 |
PDHA1 | SMPX | ENSP00000369134 | ENSP00000368808 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Deafness associated genes | 0.658 |
PDK3 | ITGB1BP2 | ENSP00000387536 | ENSP00000362935 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | 0.808 |