node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOR1 | RTKN2 | ENSP00000341785 | ENSP00000362894 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.525 |
C10orf107 | RTKN2 | ENSP00000328698 | ENSP00000362894 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.473 |
DIEXF | RTKN2 | ENSP00000419005 | ENSP00000362894 | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.693 |
DPY19L3 | KIAA0930 | ENSP00000344937 | ENSP00000251993 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | Uncharacterized protein KIAA0930; KIAA0930 | 0.581 |
DPY19L3 | RTKN2 | ENSP00000344937 | ENSP00000362894 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.478 |
KCTD5 | RTKN2 | ENSP00000301738 | ENSP00000362894 | BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.485 |
KIAA0930 | DPY19L3 | ENSP00000251993 | ENSP00000344937 | Uncharacterized protein KIAA0930; KIAA0930 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | 0.581 |
KIAA0930 | RTKN2 | ENSP00000251993 | ENSP00000362894 | Uncharacterized protein KIAA0930; KIAA0930 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.499 |
NTAN1 | RTKN2 | ENSP00000287706 | ENSP00000362894 | Protein N-terminal asparagine amidohydrolase; Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme doe [...] | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.474 |
OR2AE1 | RTKN2 | ENSP00000313936 | ENSP00000362894 | Olfactory receptor 2AE1; Odorant receptor; Olfactory receptors, family 2 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.474 |
RHOA | RTKN2 | ENSP00000400175 | ENSP00000362894 | Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated r [...] | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | 0.549 |
RTKN2 | ADIPOR1 | ENSP00000362894 | ENSP00000341785 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | 0.525 |
RTKN2 | C10orf107 | ENSP00000362894 | ENSP00000328698 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement | 0.473 |
RTKN2 | DIEXF | ENSP00000362894 | ENSP00000419005 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs | 0.693 |
RTKN2 | DPY19L3 | ENSP00000362894 | ENSP00000344937 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family | 0.478 |
RTKN2 | KCTD5 | ENSP00000362894 | ENSP00000301738 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 | 0.485 |
RTKN2 | KIAA0930 | ENSP00000362894 | ENSP00000251993 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | Uncharacterized protein KIAA0930; KIAA0930 | 0.499 |
RTKN2 | NTAN1 | ENSP00000362894 | ENSP00000287706 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | Protein N-terminal asparagine amidohydrolase; Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme doe [...] | 0.474 |
RTKN2 | OR2AE1 | ENSP00000362894 | ENSP00000313936 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | Olfactory receptor 2AE1; Odorant receptor; Olfactory receptors, family 2 | 0.474 |
RTKN2 | RHOA | ENSP00000362894 | ENSP00000400175 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing | Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated r [...] | 0.549 |