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STRINGSTRING
TIMM44 TIMM44 SCO2 SCO2 FKBP1C FKBP1C PFDN5 PFDN5 FKBP7 FKBP7 FKBP1A FKBP1A PIN4 PIN4 SNX12 SNX12 RNF44 RNF44 NKTR NKTR RRBP1 RRBP1
"PIN4" - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PIN4Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA; Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily (156 aa)    
Predicted Functional Partners:
SCO2
Protein SCO2 homolog, mitochondrial; Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2); Mitochondrial respiratory chain complex assembly factors (266 aa)
      
 
  0.833
TIMM44
Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source; Belongs to the Tim44 family (452 aa)
      
      0.822
RRBP1
Ribosome-binding protein 1; Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane (977 aa)
        
      0.820
FKBP1A
Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the FKBP-type PPIase family. FKBP1 subfamily (108 aa)
      
 
  0.775
FKBP7
Peptidylprolyl isomerase; EF-hand domain containing (222 aa)
      
 
  0.768
RNF44
Ring finger protein 44 (432 aa)
      
 
  0.764
FKBP1C
Peptidylprolyl isomerase; FK506 binding protein 1C; FKBP prolyl isomerases (108 aa)
      
 
  0.743
PFDN5
Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC; Belongs to the prefoldin subunit alpha family (154 aa)
      
        0.739
NKTR
NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases (1462 aa)
      
 
  0.711
SNX12
Sorting nexin-12; May be involved in several stages of intracellular trafficking; Sorting nexins (162 aa)
      
 
  0.700
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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