• Version:
  • 11.0 [archived version]
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RHOJ RHOJ MAGI1 MAGI1 DOCK1 DOCK1 RLF RLF KCNJ4 KCNJ4 BAI2 BAI2 TMEM211 TMEM211 GPR137C GPR137C TMEM132E TMEM132E TMEM212 TMEM212 TMEM221 TMEM221
"BAI2" - Adhesion G protein-coupled receptor B2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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BAI2Adhesion G protein-coupled receptor B2; Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT- signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity) (1584 aa)    
Predicted Functional Partners:
MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity); Membrane associated guanylate kinases (1462 aa)
     
   
  0.651
GPR137C
Integral membrane protein GPR137C; G protein-coupled receptor 137C (429 aa)
     
   
  0.581
TMEM132E
Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family (984 aa)
     
   
  0.577
TMEM212
Transmembrane protein 212 (194 aa)
           
  0.573
TMEM211
Transmembrane protein 211 (129 aa)
     
   
  0.570
TMEM221
Transmembrane protein 221 (291 aa)
           
  0.553
RLF
Zinc finger protein Rlf; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (1914 aa)
           
  0.545
RHOJ
Rho-related GTP-binding protein RhoJ; GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity); Rho family GTPases (214 aa)
           
  0.540
DOCK1
Dedicator of cytokinesis protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (1865 aa)
     
   
  0.539
KCNJ4
Inward rectifier potassium channel 4; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity); Potassium voltage-gated channel subfamily J (445 aa)
     
   
  0.525
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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