node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRB2 | GPR21 | ENSP00000362734 | ENSP00000362746 | Protein crumbs homolog 2; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress- cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-II [...] | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.440 |
CRB2 | RABGAP1 | ENSP00000362734 | ENSP00000362751 | Protein crumbs homolog 2; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress- cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-II [...] | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition | 0.473 |
CRB2 | RC3H2 | ENSP00000362734 | ENSP00000362774 | Protein crumbs homolog 2; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress- cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-II [...] | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3’-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | 0.507 |
DRD2 | GPR21 | ENSP00000354859 | ENSP00000362746 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.459 |
GPR20 | GPR21 | ENSP00000366970 | ENSP00000362746 | G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP; G protein-coupled receptors, Class A orphans | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.930 |
GPR21 | CRB2 | ENSP00000362746 | ENSP00000362734 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | Protein crumbs homolog 2; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress- cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-II [...] | 0.440 |
GPR21 | DRD2 | ENSP00000362746 | ENSP00000354859 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family | 0.459 |
GPR21 | GPR20 | ENSP00000362746 | ENSP00000366970 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP; G protein-coupled receptors, Class A orphans | 0.930 |
GPR21 | GPR4 | ENSP00000362746 | ENSP00000319744 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production; G protein-coupled receptors, Class A orphans | 0.426 |
GPR21 | RABGAP1 | ENSP00000362746 | ENSP00000362751 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition | 0.482 |
GPR21 | RC3H2 | ENSP00000362746 | ENSP00000362774 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3’-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | 0.583 |
GPR21 | SGK2 | ENSP00000362746 | ENSP00000340608 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels- SCNN1A/ENAC, K(+) channels- KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter- SLC6A19, glutamate transporter- SLC1A6/EAAT4, glutamate receptors- GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger- SLC9A3/NHE3, and the Na(+)/K(+) ATPase | 0.529 |
GPR21 | STRBP | ENSP00000362746 | ENSP00000415968 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | Spermatid perinuclear RNA-binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity) | 0.477 |
GPR21 | TMEM71 | ENSP00000362746 | ENSP00000349296 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | Transmembrane protein 71; Belongs to the TMEM71 family | 0.458 |
GPR4 | GPR21 | ENSP00000319744 | ENSP00000362746 | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production; G protein-coupled receptors, Class A orphans | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.426 |
RABGAP1 | CRB2 | ENSP00000362751 | ENSP00000362734 | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition | Protein crumbs homolog 2; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress- cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-II [...] | 0.473 |
RABGAP1 | GPR21 | ENSP00000362751 | ENSP00000362746 | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.482 |
RABGAP1 | RC3H2 | ENSP00000362751 | ENSP00000362774 | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3’-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] | 0.682 |
RABGAP1 | STRBP | ENSP00000362751 | ENSP00000415968 | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition | Spermatid perinuclear RNA-binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity) | 0.545 |
RABGAP1 | TMEM71 | ENSP00000362751 | ENSP00000349296 | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition | Transmembrane protein 71; Belongs to the TMEM71 family | 0.456 |