| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASCC3 | DDX50 | ENSP00000358159 | ENSP00000362687 | Activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation; Belongs to the helicase family | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | 0.931 |
| ASCC3 | DDX56 | ENSP00000358159 | ENSP00000258772 | Activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation; Belongs to the helicase family | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily | 0.629 |
| ASCC3 | DHX37 | ENSP00000358159 | ENSP00000311135 | Activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation; Belongs to the helicase family | Probable ATP-dependent RNA helicase DHX37; DEAH-box helicase 37 | 0.511 |
| ASCC3 | NOP56 | ENSP00000358159 | ENSP00000370589 | Activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation; Belongs to the helicase family | Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | 0.444 |
| DDX50 | ASCC3 | ENSP00000362687 | ENSP00000358159 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | Activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation; Belongs to the helicase family | 0.931 |
| DDX50 | DDX56 | ENSP00000362687 | ENSP00000258772 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily | 0.723 |
| DDX50 | DHX37 | ENSP00000362687 | ENSP00000311135 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | Probable ATP-dependent RNA helicase DHX37; DEAH-box helicase 37 | 0.727 |
| DDX50 | DQX1 | ENSP00000362687 | ENSP00000384621 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1 | 0.745 |
| DDX50 | GTPBP4 | ENSP00000362687 | ENSP00000354040 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily | 0.825 |
| DDX50 | NOP56 | ENSP00000362687 | ENSP00000370589 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | 0.772 |
| DDX50 | PNO1 | ENSP00000362687 | ENSP00000263657 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA | 0.735 |
| DDX50 | PRKRA | ENSP00000362687 | ENSP00000318176 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ’Lys-386’ at ’Ser-392’ respectively and enhances its activity i [...] | 0.775 |
| DDX50 | RSL1D1 | ENSP00000362687 | ENSP00000460871 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent | 0.703 |
| DDX50 | TARBP2 | ENSP00000362687 | ENSP00000266987 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.759 |
| DDX56 | ASCC3 | ENSP00000258772 | ENSP00000358159 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily | Activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation; Belongs to the helicase family | 0.629 |
| DDX56 | DDX50 | ENSP00000258772 | ENSP00000362687 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases | 0.723 |
| DDX56 | DHX37 | ENSP00000258772 | ENSP00000311135 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily | Probable ATP-dependent RNA helicase DHX37; DEAH-box helicase 37 | 0.959 |
| DDX56 | DQX1 | ENSP00000258772 | ENSP00000384621 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily | ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1 | 0.742 |
| DDX56 | GTPBP4 | ENSP00000258772 | ENSP00000354040 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily | 0.989 |
| DDX56 | NOP56 | ENSP00000258772 | ENSP00000370589 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily | Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | 0.984 |
