| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABTB2 | ARL15 | ENSP00000410157 | ENSP00000433427 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | 0.656 |
| ABTB2 | KDM7A | ENSP00000410157 | ENSP00000380692 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing | Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4 [...] | 0.483 |
| ABTB2 | NEK3 | ENSP00000410157 | ENSP00000484443 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing | Serine/threonine-protein kinase Nek3; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin- mediated phosphorylation of PXN and VAV2. Implicated in prolactin- mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily | 0.460 |
| ABTB2 | OLFML2A | ENSP00000410157 | ENSP00000362682 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing | Olfactomedin-like protein 2A; Olfactomedin like 2A | 0.627 |
| ARL15 | ABTB2 | ENSP00000433427 | ENSP00000410157 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing | 0.656 |
| ARL15 | OLFML2A | ENSP00000433427 | ENSP00000362682 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | Olfactomedin-like protein 2A; Olfactomedin like 2A | 0.468 |
| BCOR | OLFML2A | ENSP00000367705 | ENSP00000362682 | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] | Olfactomedin-like protein 2A; Olfactomedin like 2A | 0.534 |
| FLRT3 | OLFML2A | ENSP00000367292 | ENSP00000362682 | Leucine-rich repeat transmembrane protein FLRT3; Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Media [...] | Olfactomedin-like protein 2A; Olfactomedin like 2A | 0.583 |
| KDM7A | ABTB2 | ENSP00000380692 | ENSP00000410157 | Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4 [...] | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing | 0.483 |
| KDM7A | OLFML2A | ENSP00000380692 | ENSP00000362682 | Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4 [...] | Olfactomedin-like protein 2A; Olfactomedin like 2A | 0.485 |
| NEK3 | ABTB2 | ENSP00000484443 | ENSP00000410157 | Serine/threonine-protein kinase Nek3; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin- mediated phosphorylation of PXN and VAV2. Implicated in prolactin- mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing | 0.460 |
| NEK3 | OLFML2A | ENSP00000484443 | ENSP00000362682 | Serine/threonine-protein kinase Nek3; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin- mediated phosphorylation of PXN and VAV2. Implicated in prolactin- mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily | Olfactomedin-like protein 2A; Olfactomedin like 2A | 0.436 |
| OLFML2A | ABTB2 | ENSP00000362682 | ENSP00000410157 | Olfactomedin-like protein 2A; Olfactomedin like 2A | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing | 0.627 |
| OLFML2A | ARL15 | ENSP00000362682 | ENSP00000433427 | Olfactomedin-like protein 2A; Olfactomedin like 2A | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | 0.468 |
| OLFML2A | BCOR | ENSP00000362682 | ENSP00000367705 | Olfactomedin-like protein 2A; Olfactomedin like 2A | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] | 0.534 |
| OLFML2A | FLRT3 | ENSP00000362682 | ENSP00000367292 | Olfactomedin-like protein 2A; Olfactomedin like 2A | Leucine-rich repeat transmembrane protein FLRT3; Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Media [...] | 0.583 |
| OLFML2A | KDM7A | ENSP00000362682 | ENSP00000380692 | Olfactomedin-like protein 2A; Olfactomedin like 2A | Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4 [...] | 0.485 |
| OLFML2A | NEK3 | ENSP00000362682 | ENSP00000484443 | Olfactomedin-like protein 2A; Olfactomedin like 2A | Serine/threonine-protein kinase Nek3; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin- mediated phosphorylation of PXN and VAV2. Implicated in prolactin- mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily | 0.436 |
| OLFML2A | PARVG | ENSP00000362682 | ENSP00000391583 | Olfactomedin-like protein 2A; Olfactomedin like 2A | Gamma-parvin; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization; Belongs to the parvin family | 0.542 |
| OLFML2A | PLLP | ENSP00000362682 | ENSP00000219207 | Olfactomedin-like protein 2A; Olfactomedin like 2A | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family | 0.422 |
