node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL1 | GCC1 | ENSP00000261636 | ENSP00000318821 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | 0.959 |
ARL1 | GCC2 | ENSP00000261636 | ENSP00000307939 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | 0.973 |
ARL1 | GOLGA1 | ENSP00000261636 | ENSP00000362656 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Golgin subfamily A member 1; Probably involved in maintaining Golgi structure | 0.969 |
ARL1 | GOLGA4 | ENSP00000261636 | ENSP00000349305 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Golgin subfamily A member 4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 | 0.976 |
ARL1 | RAB6A | ENSP00000261636 | ENSP00000311449 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER; RAB, member RAS oncogene GTPases | 0.963 |
ARL1 | STX16 | ENSP00000261636 | ENSP00000360183 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family | 0.915 |
ARL1 | STX6 | ENSP00000261636 | ENSP00000258301 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Syntaxin-6; Involved in intracellular vesicle trafficking; Syntaxins | 0.922 |
ARL1 | TGOLN2 | ENSP00000261636 | ENSP00000386443 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Trans-Golgi network integral membrane protein 2; May be involved in regulating membrane traffic to and from trans-Golgi network | 0.912 |
ARL1 | TMF1 | ENSP00000261636 | ENSP00000381567 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | TATA element modulatory factor; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes- one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP) | 0.903 |
ARL1 | VTI1A | ENSP00000261636 | ENSP00000376792 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular [...] | 0.921 |
GCC1 | ARL1 | ENSP00000318821 | ENSP00000261636 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | 0.959 |
GCC1 | GCC2 | ENSP00000318821 | ENSP00000307939 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | 0.941 |
GCC1 | GOLGA1 | ENSP00000318821 | ENSP00000362656 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | Golgin subfamily A member 1; Probably involved in maintaining Golgi structure | 0.981 |
GCC1 | GOLGA4 | ENSP00000318821 | ENSP00000349305 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | Golgin subfamily A member 4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 | 0.981 |
GCC1 | RAB6A | ENSP00000318821 | ENSP00000311449 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER; RAB, member RAS oncogene GTPases | 0.950 |
GCC1 | STX16 | ENSP00000318821 | ENSP00000360183 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family | 0.963 |
GCC1 | STX6 | ENSP00000318821 | ENSP00000258301 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | Syntaxin-6; Involved in intracellular vesicle trafficking; Syntaxins | 0.949 |
GCC1 | TGOLN2 | ENSP00000318821 | ENSP00000386443 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | Trans-Golgi network integral membrane protein 2; May be involved in regulating membrane traffic to and from trans-Golgi network | 0.965 |
GCC1 | TMF1 | ENSP00000318821 | ENSP00000381567 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | TATA element modulatory factor; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes- one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP) | 0.952 |
GCC1 | VTI1A | ENSP00000318821 | ENSP00000376792 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure | Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular [...] | 0.948 |