node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACVR1B | BRIX1 | ENSP00000442656 | ENSP00000338862 | Activin receptor type-1B; Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine [...] | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | 0.456 |
ACVR1B | MTL5 | ENSP00000442656 | ENSP00000255087 | Activin receptor type-1B; Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine [...] | Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family | 0.464 |
ACVR1B | TSSK3 | ENSP00000442656 | ENSP00000362634 | Activin receptor type-1B; Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine [...] | Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function | 0.530 |
BRIX1 | ACVR1B | ENSP00000338862 | ENSP00000442656 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Activin receptor type-1B; Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine [...] | 0.456 |
BRIX1 | CCNI | ENSP00000338862 | ENSP00000237654 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Cyclin-I; Cyclin I; Belongs to the cyclin family | 0.499 |
BRIX1 | CCT6B | ENSP00000338862 | ENSP00000327191 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | T-complex protein 1 subunit zeta-2; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); Chaperonins | 0.473 |
BRIX1 | DNAJA1 | ENSP00000338862 | ENSP00000369127 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV; DNAJ heat shock proteins | 0.495 |
BRIX1 | MTL5 | ENSP00000338862 | ENSP00000255087 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family | 0.644 |
BRIX1 | TSSK3 | ENSP00000338862 | ENSP00000362634 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function | 0.664 |
CCNI | BRIX1 | ENSP00000237654 | ENSP00000338862 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | 0.499 |
CCNI | MTL5 | ENSP00000237654 | ENSP00000255087 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family | 0.541 |
CCNI | TSSK3 | ENSP00000237654 | ENSP00000362634 | Cyclin-I; Cyclin I; Belongs to the cyclin family | Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function | 0.645 |
CCT6B | BRIX1 | ENSP00000327191 | ENSP00000338862 | T-complex protein 1 subunit zeta-2; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); Chaperonins | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | 0.473 |
CCT6B | DNAJA1 | ENSP00000327191 | ENSP00000369127 | T-complex protein 1 subunit zeta-2; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); Chaperonins | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV; DNAJ heat shock proteins | 0.850 |
CCT6B | HSF2BP | ENSP00000327191 | ENSP00000291560 | T-complex protein 1 subunit zeta-2; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); Chaperonins | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity); Armadillo-like helical domain containing | 0.485 |
CCT6B | TSSK3 | ENSP00000327191 | ENSP00000362634 | T-complex protein 1 subunit zeta-2; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); Chaperonins | Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function | 0.536 |
CCT6B | TXNDC2 | ENSP00000327191 | ENSP00000304908 | T-complex protein 1 subunit zeta-2; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); Chaperonins | Thioredoxin domain-containing protein 2; Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase | 0.415 |
DNAJA1 | BRIX1 | ENSP00000369127 | ENSP00000338862 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV; DNAJ heat shock proteins | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | 0.495 |
DNAJA1 | CCT6B | ENSP00000369127 | ENSP00000327191 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV; DNAJ heat shock proteins | T-complex protein 1 subunit zeta-2; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); Chaperonins | 0.850 |
DNAJA1 | MTL5 | ENSP00000369127 | ENSP00000255087 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV; DNAJ heat shock proteins | Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family | 0.430 |