node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHGA | VSTM2L | ENSP00000216492 | ENSP00000362560 | Chromogranin-A; Pancreastatin- Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like | 0.510 |
CTXN1 | FBXW9 | ENSP00000313226 | ENSP00000376945 | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development | F-box/WD repeat-containing protein 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | 0.530 |
CTXN1 | LY6H | ENSP00000313226 | ENSP00000399485 | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons; LY6/PLAUR domain containing | 0.577 |
CTXN1 | VSTM2L | ENSP00000313226 | ENSP00000362560 | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like | 0.612 |
EFCAB8 | VSTM2L | ENSP00000383366 | ENSP00000362560 | EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8 | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like | 0.642 |
FBXW9 | CTXN1 | ENSP00000376945 | ENSP00000313226 | F-box/WD repeat-containing protein 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development | 0.530 |
FBXW9 | LY6H | ENSP00000376945 | ENSP00000399485 | F-box/WD repeat-containing protein 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons; LY6/PLAUR domain containing | 0.464 |
FBXW9 | TRIM11 | ENSP00000376945 | ENSP00000284551 | F-box/WD repeat-containing protein 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation [...] | 0.900 |
FBXW9 | VSTM2L | ENSP00000376945 | ENSP00000362560 | F-box/WD repeat-containing protein 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like | 0.521 |
GNG4 | RCAN2 | ENSP00000375727 | ENSP00000360425 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs to the RCAN family | 0.434 |
GNG4 | VSTM2L | ENSP00000375727 | ENSP00000362560 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like | 0.467 |
GNG4 | ZNF385B | ENSP00000375727 | ENSP00000386845 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis | 0.416 |
LY6H | CTXN1 | ENSP00000399485 | ENSP00000313226 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons; LY6/PLAUR domain containing | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development | 0.577 |
LY6H | FBXW9 | ENSP00000399485 | ENSP00000376945 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons; LY6/PLAUR domain containing | F-box/WD repeat-containing protein 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | 0.464 |
LY6H | VSTM2L | ENSP00000399485 | ENSP00000362560 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons; LY6/PLAUR domain containing | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like | 0.651 |
MPHOSPH8 | TRIM11 | ENSP00000355388 | ENSP00000284551 | M-phase phosphoprotein 8; Heterochromatin component that specifically recognizes and binds methylated ’Lys-9’ of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites- the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can [...] | E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation [...] | 0.639 |
MPHOSPH8 | VSTM2L | ENSP00000355388 | ENSP00000362560 | M-phase phosphoprotein 8; Heterochromatin component that specifically recognizes and binds methylated ’Lys-9’ of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites- the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can [...] | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like | 0.597 |
RCAN2 | GNG4 | ENSP00000360425 | ENSP00000375727 | Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs to the RCAN family | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.434 |
RCAN2 | VSTM2L | ENSP00000360425 | ENSP00000362560 | Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs to the RCAN family | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like | 0.500 |
RCAN2 | ZNF385B | ENSP00000360425 | ENSP00000386845 | Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs to the RCAN family | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis | 0.487 |