| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AUH | HMGB4 | ENSP00000364883 | ENSP00000430919 | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | Canonical high mobility group; Belongs to the HMGB family | 0.522 |
| AUH | ZBTB34 | ENSP00000364883 | ENSP00000362551 | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.573 |
| GABRR3 | LRRC48 | ENSP00000481321 | ENSP00000382140 | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility | 0.476 |
| GABRR3 | RHBDD2 | ENSP00000481321 | ENSP00000006777 | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Rhomboid domain containing 2; Belongs to the peptidase S54 family | 0.547 |
| GABRR3 | ZBTB34 | ENSP00000481321 | ENSP00000362551 | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.531 |
| HMGB4 | AUH | ENSP00000430919 | ENSP00000364883 | Canonical high mobility group; Belongs to the HMGB family | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.522 |
| HMGB4 | ZBTB34 | ENSP00000430919 | ENSP00000362551 | Canonical high mobility group; Belongs to the HMGB family | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.526 |
| LGALS4 | ZBTB34 | ENSP00000302100 | ENSP00000362551 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.649 |
| LRP5L | ZBTB34 | ENSP00000482378 | ENSP00000362551 | Low-density lipoprotein receptor-related protein 5-like protein; LDL receptor related protein 5 like | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.532 |
| LRRC48 | GABRR3 | ENSP00000382140 | ENSP00000481321 | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.476 |
| LRRC48 | RHBDD2 | ENSP00000382140 | ENSP00000006777 | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility | Rhomboid domain containing 2; Belongs to the peptidase S54 family | 0.578 |
| LRRC48 | ZBTB34 | ENSP00000382140 | ENSP00000362551 | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.525 |
| POLR1B | TASP1 | ENSP00000444136 | ENSP00000338624 | DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | Threonine aspartase 1; Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster; Belongs to the Ntn-hydrolase family | 0.663 |
| POLR1B | TCEA1 | ENSP00000444136 | ENSP00000428426 | DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | Transcription elongation factor A protein 1; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3’-terminus; General transcription factors | 0.643 |
| POLR1B | ZBTB34 | ENSP00000444136 | ENSP00000362551 | DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.720 |
| RHBDD2 | GABRR3 | ENSP00000006777 | ENSP00000481321 | Rhomboid domain containing 2; Belongs to the peptidase S54 family | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.547 |
| RHBDD2 | LRRC48 | ENSP00000006777 | ENSP00000382140 | Rhomboid domain containing 2; Belongs to the peptidase S54 family | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility | 0.578 |
| RHBDD2 | ZBTB34 | ENSP00000006777 | ENSP00000362551 | Rhomboid domain containing 2; Belongs to the peptidase S54 family | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.591 |
| TASP1 | POLR1B | ENSP00000338624 | ENSP00000444136 | Threonine aspartase 1; Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster; Belongs to the Ntn-hydrolase family | DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | 0.663 |
| TASP1 | ZBTB34 | ENSP00000338624 | ENSP00000362551 | Threonine aspartase 1; Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster; Belongs to the Ntn-hydrolase family | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing | 0.704 |
