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STRINGSTRING
CCDC107 CCDC107 LMNTD1 LMNTD1 B3GALT5 B3GALT5 GAPT GAPT GARNL3 GARNL3 TSPEAR TSPEAR RALGPS1 RALGPS1 CADPS CADPS DUXA DUXA ZNF264 ZNF264 RGS8 RGS8
"GARNL3" - GTPase-activating Rap/Ran-GAP domain-like protein 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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GARNL3GTPase-activating Rap/Ran-GAP domain-like protein 3; GTPase activating Rap/RanGAP domain like 3 (1013 aa)    
Predicted Functional Partners:
RALGPS1
Ras-specific guanine nucleotide-releasing factor RalGPS1; Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for; Pleckstrin homology domain containing (557 aa)
      
   
  0.659
LMNTD1
Lamin tail domain containing 1 (409 aa)
            
  0.645
TSPEAR
Thrombospondin-type laminin G domain and EAR repeat-containing protein; May play a role in development or function of the auditory system; Deafness associated genes (669 aa)
            
  0.606
GAPT
Protein GAPT; Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity); Belongs to the GAPT family (157 aa)
            
  0.585
DUXA
Double homeobox protein A; Putative transcription factor; PRD class homeoboxes and pseudogenes (204 aa)
      
   
  0.566
ZNF264
Zinc finger protein 264; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (627 aa)
        
 
  0.552
CADPS
Calcium-dependent secretion activator 1; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in [...] (1353 aa)
      
   
  0.545
B3GALT5
Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor; Belongs to the glycosyltransferase 31 family (314 aa)
            
  0.533
CCDC107
Coiled-coil domain containing 107 (283 aa)
            
  0.524
RGS8
Regulator of G-protein signaling 8; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity) (198 aa)
      
   
  0.499
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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