• Version:
  • 11.0 [archived version]
STRINGSTRING
FOXP2 FOXP2 CDC37L1 CDC37L1 KCTD15 KCTD15 KCNIP4 KCNIP4 CSMD2 CSMD2 KDELC2 KDELC2 TMEM40 TMEM40 CTSB CTSB FDFT1 FDFT1 NRDE2 NRDE2 SKAP2 SKAP2
"CSMD2" - CUB and Sushi multiple domains 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CSMD2CUB and Sushi multiple domains 2 (3631 aa)    
Predicted Functional Partners:
FDFT1
Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 (417 aa)
           
  0.644
CDC37L1
Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 (337 aa)
           
  0.630
CTSB
Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins (339 aa)
           
  0.628
KCTD15
BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain (283 aa)
           
  0.600
SKAP2
Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway; Belongs to the SKAP family (359 aa)
           
  0.577
KDELC2
KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family (507 aa)
           
  0.537
NRDE2
Protein NRDE2 homolog; NRDE-2, necessary for RNA interference, domain containing; Belongs to the NRDE2 family (1164 aa)
           
  0.527
TMEM40
Transmembrane protein 40 (233 aa)
           
  0.493
KCNIP4
Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family (250 aa)
       
 
  0.490
FOXP2
Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language; Forkhead boxes (740 aa)
     
   
  0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]