node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC37L1 | CSMD2 | ENSP00000371278 | ENSP00000362479 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 | CUB and Sushi multiple domains 2 | 0.630 |
CSMD2 | CDC37L1 | ENSP00000362479 | ENSP00000371278 | CUB and Sushi multiple domains 2 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 | 0.630 |
CSMD2 | CTSB | ENSP00000362479 | ENSP00000345672 | CUB and Sushi multiple domains 2 | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | 0.628 |
CSMD2 | FDFT1 | ENSP00000362479 | ENSP00000480828 | CUB and Sushi multiple domains 2 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | 0.644 |
CSMD2 | FOXP2 | ENSP00000362479 | ENSP00000386200 | CUB and Sushi multiple domains 2 | Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language; Forkhead boxes | 0.479 |
CSMD2 | KCNIP4 | ENSP00000362479 | ENSP00000371587 | CUB and Sushi multiple domains 2 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family | 0.490 |
CSMD2 | KCTD15 | ENSP00000362479 | ENSP00000394390 | CUB and Sushi multiple domains 2 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | 0.600 |
CSMD2 | KDELC2 | ENSP00000362479 | ENSP00000315386 | CUB and Sushi multiple domains 2 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | 0.537 |
CSMD2 | NRDE2 | ENSP00000362479 | ENSP00000346335 | CUB and Sushi multiple domains 2 | Protein NRDE2 homolog; NRDE-2, necessary for RNA interference, domain containing; Belongs to the NRDE2 family | 0.527 |
CSMD2 | SKAP2 | ENSP00000362479 | ENSP00000005587 | CUB and Sushi multiple domains 2 | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway; Belongs to the SKAP family | 0.577 |
CSMD2 | TMEM40 | ENSP00000362479 | ENSP00000322837 | CUB and Sushi multiple domains 2 | Transmembrane protein 40 | 0.493 |
CTSB | CSMD2 | ENSP00000345672 | ENSP00000362479 | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | CUB and Sushi multiple domains 2 | 0.628 |
CTSB | FDFT1 | ENSP00000345672 | ENSP00000480828 | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | 0.469 |
FDFT1 | CSMD2 | ENSP00000480828 | ENSP00000362479 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | CUB and Sushi multiple domains 2 | 0.644 |
FDFT1 | CTSB | ENSP00000480828 | ENSP00000345672 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | 0.469 |
FDFT1 | SKAP2 | ENSP00000480828 | ENSP00000005587 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway; Belongs to the SKAP family | 0.525 |
FOXP2 | CSMD2 | ENSP00000386200 | ENSP00000362479 | Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language; Forkhead boxes | CUB and Sushi multiple domains 2 | 0.479 |
KCNIP4 | CSMD2 | ENSP00000371587 | ENSP00000362479 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane; Belongs to the recoverin family | CUB and Sushi multiple domains 2 | 0.490 |
KCTD15 | CSMD2 | ENSP00000394390 | ENSP00000362479 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | CUB and Sushi multiple domains 2 | 0.600 |
KDELC2 | CSMD2 | ENSP00000315386 | ENSP00000362479 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | CUB and Sushi multiple domains 2 | 0.537 |