| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC5L | FAM129B | ENSP00000360532 | ENSP00000362409 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.980 |
| EGFR | FAM129B | ENSP00000275493 | ENSP00000362409 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.626 |
| EGFR | KEAP1 | ENSP00000275493 | ENSP00000171111 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | Kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome; BTB domain containing | 0.647 |
| FAM129B | CDC5L | ENSP00000362409 | ENSP00000360532 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | 0.980 |
| FAM129B | EGFR | ENSP00000362409 | ENSP00000275493 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | 0.626 |
| FAM129B | FAM3C | ENSP00000362409 | ENSP00000353025 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition | 0.507 |
| FAM129B | FAM83H | ENSP00000362409 | ENSP00000373565 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration | 0.570 |
| FAM129B | HS1BP3 | ENSP00000362409 | ENSP00000305193 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | HCLS1-binding protein 3; May be a modulator of IL-2 signaling | 0.497 |
| FAM129B | KEAP1 | ENSP00000362409 | ENSP00000171111 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | Kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome; BTB domain containing | 0.630 |
| FAM129B | OR8G1 | ENSP00000362409 | ENSP00000476313 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | Olfactory receptor 8G1; Odorant receptor; Olfactory receptors, family 8 | 0.557 |
| FAM129B | RAI14 | ENSP00000362409 | ENSP00000427123 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | Ankycorbin; Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier; Ankyrin repeat domain containing | 0.523 |
| FAM129B | WDR72 | ENSP00000362409 | ENSP00000379619 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane; WD repeat domain containing | 0.498 |
| FAM129B | ZNF777 | ENSP00000362409 | ENSP00000247930 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | Zinc finger protein 777; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.547 |
| FAM3C | FAM129B | ENSP00000353025 | ENSP00000362409 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.507 |
| FAM83H | FAM129B | ENSP00000373565 | ENSP00000362409 | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.570 |
| FAM83H | WDR72 | ENSP00000373565 | ENSP00000379619 | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane; WD repeat domain containing | 0.884 |
| HS1BP3 | FAM129B | ENSP00000305193 | ENSP00000362409 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.497 |
| KEAP1 | EGFR | ENSP00000171111 | ENSP00000275493 | Kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome; BTB domain containing | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | 0.647 |
| KEAP1 | FAM129B | ENSP00000171111 | ENSP00000362409 | Kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome; BTB domain containing | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.630 |
| OR8G1 | FAM129B | ENSP00000476313 | ENSP00000362409 | Olfactory receptor 8G1; Odorant receptor; Olfactory receptors, family 8 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.557 |
