• Version:
  • 11.0 [archived version]
STRINGSTRING
PTGFRN PTGFRN TSPAN2 TSPAN2 TSPAN31 TSPAN31 TMEM125 TMEM125 BTRC BTRC TSPAN32 TSPAN32 TSPAN15 TSPAN15 TSPAN13 TSPAN13 SLC44A2 SLC44A2 ADAM10 ADAM10 TSPAN12 TSPAN12
"TSPAN15" - Tetraspanin-15 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TSPAN15Tetraspanin-15; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity; Belongs to the tetraspanin (TM4SF) family (294 aa)    
Predicted Functional Partners:
TSPAN13
Tetraspanin-13; Tetraspanin 13; Tetraspanins (204 aa)
     
   
  0.765
TSPAN12
Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also p [...] (305 aa)
     
   
  0.702
ADAM10
Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77’ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cle [...] (748 aa)
     
 
  0.698
TSPAN32
Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family (320 aa)
           
  0.649
TSPAN2
Tetraspanin-2; May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath; Belongs to the tetraspanin (TM4SF) family (221 aa)
     
 
  0.609
BTRC
F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at ’Lys- 21 [...] (605 aa)
       
 
  0.591
SLC44A2
Choline transporter-like protein 2; Isoform 1, but not isoform 3, exhibits some choline transporter activity; Solute carriers (706 aa)
           
  0.579
PTGFRN
Prostaglandin F2 receptor negative regulator; Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity); CD molecules (879 aa)
     
 
  0.578
TSPAN31
Tetraspanin-31; Tetraspanin 31; Tetraspanins (210 aa)
     
   
  0.563
TMEM125
Transmembrane protein 125 (219 aa)
     
   
  0.554
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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