| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BPIFB3 | LOC728763 | ENSP00000364643 | ENSP00000397968 | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family | 0.448 |
| BPIFB3 | PCDHB6 | ENSP00000364643 | ENSP00000231136 | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | Protocadherin beta-6; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.421 |
| BPIFB3 | TEX261 | ENSP00000364643 | ENSP00000272438 | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | Protein TEX261; Testis expressed 261 | 0.567 |
| BPIFB3 | TM4SF20 | ENSP00000364643 | ENSP00000303028 | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.513 |
| BPIFB3 | TMEM14B | ENSP00000364643 | ENSP00000420658 | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | Transmembrane protein 14B | 0.472 |
| BPIFB3 | TTC16 | ENSP00000364643 | ENSP00000362386 | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | Tetratricopeptide repeat domain containing | 0.633 |
| DEPDC5 | OR12D2 | ENSP00000383105 | ENSP00000373047 | GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway | Olfactory receptor 12D2; Odorant receptor; Olfactory receptors, family 12 | 0.535 |
| DEPDC5 | SLC6A18 | ENSP00000383105 | ENSP00000323549 | GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | 0.401 |
| DEPDC5 | TTC16 | ENSP00000383105 | ENSP00000362386 | GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway | Tetratricopeptide repeat domain containing | 0.605 |
| LOC728763 | BPIFB3 | ENSP00000397968 | ENSP00000364643 | Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing | 0.448 |
| LOC728763 | PCDHB6 | ENSP00000397968 | ENSP00000231136 | Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family | Protocadherin beta-6; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.440 |
| LOC728763 | TEX261 | ENSP00000397968 | ENSP00000272438 | Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family | Protein TEX261; Testis expressed 261 | 0.552 |
| LOC728763 | TM4SF20 | ENSP00000397968 | ENSP00000303028 | Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.426 |
| LOC728763 | TMEM14B | ENSP00000397968 | ENSP00000420658 | Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family | Transmembrane protein 14B | 0.502 |
| LOC728763 | TTC16 | ENSP00000397968 | ENSP00000362386 | Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family | Tetratricopeptide repeat domain containing | 0.641 |
| OR12D2 | DEPDC5 | ENSP00000373047 | ENSP00000383105 | Olfactory receptor 12D2; Odorant receptor; Olfactory receptors, family 12 | GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway | 0.535 |
| OR12D2 | SLC6A18 | ENSP00000373047 | ENSP00000323549 | Olfactory receptor 12D2; Odorant receptor; Olfactory receptors, family 12 | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | 0.581 |
| OR12D2 | TTC16 | ENSP00000373047 | ENSP00000362386 | Olfactory receptor 12D2; Odorant receptor; Olfactory receptors, family 12 | Tetratricopeptide repeat domain containing | 0.732 |
| OR4K5 | SLC6A18 | ENSP00000319511 | ENSP00000323549 | Olfactory receptor 4K5; Odorant receptor; Olfactory receptors, family 4 | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | 0.472 |
| OR4K5 | TTC16 | ENSP00000319511 | ENSP00000362386 | Olfactory receptor 4K5; Odorant receptor; Olfactory receptors, family 4 | Tetratricopeptide repeat domain containing | 0.646 |
