C10orf35 protein (human) - STRING database

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C10orf35

Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35 (121 aa)

Predicted Functional Partners:

CACNG7

0.569

TSPAN15

0.543

AHRR

0.537

HKDC1

0.531

MOSPD1

0.510

SFMBT2

0.491

SUPV3L1

0.491

COL13A1

0.473

HOXD12

0.465

FBLN2

0.409

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHRR	C10orf35	ENSP00000323816	ENSP00000362376	Aryl hydrocarbon receptor repressor; Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site; Basic helix-loop-helix proteins	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.537
C10orf35	AHRR	ENSP00000362376	ENSP00000323816	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Aryl hydrocarbon receptor repressor; Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site; Basic helix-loop-helix proteins	0.537
C10orf35	CACNG7	ENSP00000362376	ENSP00000375647	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Voltage-dependent calcium channel gamma-7 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily	0.569
C10orf35	COL13A1	ENSP00000362376	ENSP00000381949	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Collagen alpha-1(XIII) chain; Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering; Collagens	0.473
C10orf35	FBLN2	ENSP00000362376	ENSP00000384169	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN; Fibulins	0.409
C10orf35	HKDC1	ENSP00000362376	ENSP00000346643	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Putative hexokinase HKDC1; Hexokinase domain containing 1	0.531
C10orf35	HOXD12	ENSP00000362376	ENSP00000385586	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family	0.465
C10orf35	MOSPD1	ENSP00000362376	ENSP00000359819	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation	0.510
C10orf35	SFMBT2	ENSP00000362376	ENSP00000380353	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Scm-like with four MBT domains protein 2; Transcriptional repressor of HOXB13 gene; MBT domain containing	0.491
C10orf35	SUPV3L1	ENSP00000362376	ENSP00000352678	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3’ overhang double-stranded RNA with a 3’-to-5’ directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5’-to-3’ direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation [...]	0.491
C10orf35	TSPAN15	ENSP00000362376	ENSP00000362387	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	Tetraspanin-15; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity; Belongs to the tetraspanin (TM4SF) family	0.543
CACNG7	C10orf35	ENSP00000375647	ENSP00000362376	Voltage-dependent calcium channel gamma-7 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.569
COL13A1	C10orf35	ENSP00000381949	ENSP00000362376	Collagen alpha-1(XIII) chain; Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering; Collagens	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.473
FBLN2	C10orf35	ENSP00000384169	ENSP00000362376	Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN; Fibulins	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.409
HKDC1	C10orf35	ENSP00000346643	ENSP00000362376	Putative hexokinase HKDC1; Hexokinase domain containing 1	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.531
HKDC1	SUPV3L1	ENSP00000346643	ENSP00000352678	Putative hexokinase HKDC1; Hexokinase domain containing 1	ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3’ overhang double-stranded RNA with a 3’-to-5’ directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5’-to-3’ direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation [...]	0.670
HOXD12	C10orf35	ENSP00000385586	ENSP00000362376	Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.465
MOSPD1	C10orf35	ENSP00000359819	ENSP00000362376	Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.510
SFMBT2	C10orf35	ENSP00000380353	ENSP00000362376	Scm-like with four MBT domains protein 2; Transcriptional repressor of HOXB13 gene; MBT domain containing	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.491
SUPV3L1	C10orf35	ENSP00000352678	ENSP00000362376	ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3’ overhang double-stranded RNA with a 3’-to-5’ directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5’-to-3’ direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation [...]	Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35	0.491

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