node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHIC1 | SH3BGRL | ENSP00000362601 | ENSP00000362308 | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | 0.560 |
CMTM6 | SH3BGRL | ENSP00000205636 | ENSP00000362308 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | 0.548 |
CNGB1 | SH3BGRL | ENSP00000251102 | ENSP00000362308 | Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | 0.810 |
COTL1 | SH3BGRL | ENSP00000262428 | ENSP00000362308 | Coactosin-like protein; Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | 0.558 |
EGFR | ERBB2 | ENSP00000275493 | ENSP00000269571 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.971 |
EGFR | SH3BGRL | ENSP00000275493 | ENSP00000362308 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | 0.752 |
EGFR | STAT6 | ENSP00000275493 | ENSP00000300134 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | Signal transducer and activator of transcription 6; Carries out a dual function- signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling; SH2 domain containing | 0.663 |
ERBB2 | EGFR | ENSP00000269571 | ENSP00000275493 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | 0.971 |
ERBB2 | SH3BGRL | ENSP00000269571 | ENSP00000362308 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | 0.744 |
ERBB2 | STAT6 | ENSP00000269571 | ENSP00000300134 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Signal transducer and activator of transcription 6; Carries out a dual function- signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling; SH2 domain containing | 0.414 |
HMGN1 | SH3BGRL | ENSP00000370125 | ENSP00000362308 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity); Belongs to the HMGN family | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | 0.756 |
SH3BGRL | CHIC1 | ENSP00000362308 | ENSP00000362601 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | 0.560 |
SH3BGRL | CMTM6 | ENSP00000362308 | ENSP00000205636 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family | 0.548 |
SH3BGRL | CNGB1 | ENSP00000362308 | ENSP00000251102 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | 0.810 |
SH3BGRL | COTL1 | ENSP00000362308 | ENSP00000262428 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | Coactosin-like protein; Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis | 0.558 |
SH3BGRL | EGFR | ENSP00000362308 | ENSP00000275493 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] | 0.752 |
SH3BGRL | ERBB2 | ENSP00000362308 | ENSP00000269571 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.744 |
SH3BGRL | HMGN1 | ENSP00000362308 | ENSP00000370125 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity); Belongs to the HMGN family | 0.756 |
SH3BGRL | SNRPF | ENSP00000362308 | ENSP00000266735 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | Small nuclear ribonucleoprotein F; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.817 |
SH3BGRL | STAT6 | ENSP00000362308 | ENSP00000300134 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like | Signal transducer and activator of transcription 6; Carries out a dual function- signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling; SH2 domain containing | 0.737 |