MAP7D1 protein (human) - STRING database

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MAP7D1

MAP7 domain containing 1; Belongs to the MAP7 family (841 aa)

Predicted Functional Partners:

MAP9

0.569

NUTF2

0.561

NCAPD2

0.537

TUBGCP3

0.519

HAUS6

0.514

SMC4

0.491

DCLK1

0.479

GPN2

0.462

SMC2

0.451

SPAG5

0.450

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCLK1	MAP7D1	ENSP00000255448	ENSP00000362244	Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system; Doublecortin superfamily	MAP7 domain containing 1; Belongs to the MAP7 family	0.479
GPN2	MAP7D1	ENSP00000363250	ENSP00000362244	GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; GPN-loop GTPases	MAP7 domain containing 1; Belongs to the MAP7 family	0.462
HAUS6	MAP7D1	ENSP00000369871	ENSP00000362244	HAUS augmin-like complex subunit 6; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin; Belongs to the HAUS6 family	MAP7 domain containing 1; Belongs to the MAP7 family	0.514
HAUS6	SMC2	ENSP00000369871	ENSP00000286398	HAUS augmin-like complex subunit 6; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin; Belongs to the HAUS6 family	Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC2 subfamily	0.528
HAUS6	TUBGCP3	ENSP00000369871	ENSP00000261965	HAUS augmin-like complex subunit 6; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin; Belongs to the HAUS6 family	Gamma-tubulin complex component 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.940
MAP7D1	DCLK1	ENSP00000362244	ENSP00000255448	MAP7 domain containing 1; Belongs to the MAP7 family	Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system; Doublecortin superfamily	0.479
MAP7D1	GPN2	ENSP00000362244	ENSP00000363250	MAP7 domain containing 1; Belongs to the MAP7 family	GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; GPN-loop GTPases	0.462
MAP7D1	HAUS6	ENSP00000362244	ENSP00000369871	MAP7 domain containing 1; Belongs to the MAP7 family	HAUS augmin-like complex subunit 6; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin; Belongs to the HAUS6 family	0.514
MAP7D1	MAP9	ENSP00000362244	ENSP00000310593	MAP7 domain containing 1; Belongs to the MAP7 family	Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules	0.569
MAP7D1	NCAPD2	ENSP00000362244	ENSP00000325017	MAP7 domain containing 1; Belongs to the MAP7 family	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain; Belongs to the CND1 (condensin subunit 1) family	0.537
MAP7D1	NUTF2	ENSP00000362244	ENSP00000219169	MAP7 domain containing 1; Belongs to the MAP7 family	Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import	0.561
MAP7D1	SMC2	ENSP00000362244	ENSP00000286398	MAP7 domain containing 1; Belongs to the MAP7 family	Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC2 subfamily	0.451
MAP7D1	SMC4	ENSP00000362244	ENSP00000349961	MAP7 domain containing 1; Belongs to the MAP7 family	Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases	0.491
MAP7D1	SPAG5	ENSP00000362244	ENSP00000323300	MAP7 domain containing 1; Belongs to the MAP7 family	Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CD [...]	0.450
MAP7D1	TUBGCP3	ENSP00000362244	ENSP00000261965	MAP7 domain containing 1; Belongs to the MAP7 family	Gamma-tubulin complex component 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.519
MAP9	MAP7D1	ENSP00000310593	ENSP00000362244	Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules	MAP7 domain containing 1; Belongs to the MAP7 family	0.569
NCAPD2	MAP7D1	ENSP00000325017	ENSP00000362244	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain; Belongs to the CND1 (condensin subunit 1) family	MAP7 domain containing 1; Belongs to the MAP7 family	0.537
NCAPD2	SMC2	ENSP00000325017	ENSP00000286398	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain; Belongs to the CND1 (condensin subunit 1) family	Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC2 subfamily	0.999
NCAPD2	SMC4	ENSP00000325017	ENSP00000349961	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain; Belongs to the CND1 (condensin subunit 1) family	Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases	0.999
NCAPD2	SPAG5	ENSP00000325017	ENSP00000323300	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain; Belongs to the CND1 (condensin subunit 1) family	Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CD [...]	0.692

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