| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DPM2 | FAM102A | ENSP00000322181 | ENSP00000362187 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | 0.596 |
| EHBP1 | FAM102A | ENSP00000263991 | ENSP00000362187 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity); NT-C2 domain containing | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | 0.636 |
| ESR1 | FAM102A | ENSP00000405330 | ENSP00000362187 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | 0.526 |
| FAM102A | DPM2 | ENSP00000362187 | ENSP00000322181 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity | 0.596 |
| FAM102A | EHBP1 | ENSP00000362187 | ENSP00000263991 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity); NT-C2 domain containing | 0.636 |
| FAM102A | ESR1 | ENSP00000362187 | ENSP00000405330 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.526 |
| FAM102A | PCMT1 | ENSP00000362187 | ENSP00000356354 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine- binding protein 1, stathmin, beta-synuclein and alpha-synuclein; Seven-beta-strand methyltransfera [...] | 0.553 |
| FAM102A | SGTB | ENSP00000362187 | ENSP00000370395 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity; Tetratricopeptide repeat domain containing | 0.688 |
| FAM102A | SIRPB2 | ENSP00000362187 | ENSP00000352849 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | Signal-regulatory protein beta-2; Signal regulatory protein beta 2 | 0.528 |
| FAM102A | SKAP1 | ENSP00000362187 | ENSP00000338171 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | Src kinase-associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells; Belongs to the SKAP family | 0.749 |
| FAM102A | SRMS | ENSP00000362187 | ENSP00000217188 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | Tyrosine-protein kinase Srms; Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin; SH2 domain containing | 0.519 |
| FAM102A | TRAPPC5 | ENSP00000362187 | ENSP00000470262 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily | 0.510 |
| FAM102A | WDR44 | ENSP00000362187 | ENSP00000254029 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | WD repeat-containing protein 44; Downstream effector for RAB11. May be involved in vesicle recycling (By similarity); WD repeat domain containing | 0.712 |
| PCMT1 | FAM102A | ENSP00000356354 | ENSP00000362187 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine- binding protein 1, stathmin, beta-synuclein and alpha-synuclein; Seven-beta-strand methyltransfera [...] | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | 0.553 |
| PCMT1 | SGTB | ENSP00000356354 | ENSP00000370395 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine- binding protein 1, stathmin, beta-synuclein and alpha-synuclein; Seven-beta-strand methyltransfera [...] | Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity; Tetratricopeptide repeat domain containing | 0.542 |
| SGTB | FAM102A | ENSP00000370395 | ENSP00000362187 | Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity; Tetratricopeptide repeat domain containing | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | 0.688 |
| SGTB | PCMT1 | ENSP00000370395 | ENSP00000356354 | Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity; Tetratricopeptide repeat domain containing | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine- binding protein 1, stathmin, beta-synuclein and alpha-synuclein; Seven-beta-strand methyltransfera [...] | 0.542 |
| SGTB | SRMS | ENSP00000370395 | ENSP00000217188 | Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity; Tetratricopeptide repeat domain containing | Tyrosine-protein kinase Srms; Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin; SH2 domain containing | 0.441 |
| SIRPB2 | FAM102A | ENSP00000352849 | ENSP00000362187 | Signal-regulatory protein beta-2; Signal regulatory protein beta 2 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | 0.528 |
| SKAP1 | FAM102A | ENSP00000338171 | ENSP00000362187 | Src kinase-associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells; Belongs to the SKAP family | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family | 0.749 |
