MANEAL protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Score

MANEAL

Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family (457 aa)

Predicted Functional Partners:

DISP2

0.669

AKIRIN1

0.623

AKIRIN2

0.601

TMEM161A

0.597

NT5C1A

0.561

FAM124B

0.553

ST3GAL4

0.548

PNRC1

0.547

ANKRD34A

0.525

RRAGD

0.522

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKIRIN1	AKIRIN2	ENSP00000392678	ENSP00000257787	Akirin-1; Akirin 1	Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family	0.870
AKIRIN1	MANEAL	ENSP00000392678	ENSP00000362136	Akirin-1; Akirin 1	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	0.623
AKIRIN1	NT5C1A	ENSP00000392678	ENSP00000235628	Akirin-1; Akirin 1	Cytosolic 5’-nucleotidase 1A; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia; 5’-nucleotidases	0.447
AKIRIN1	PNRC1	ENSP00000392678	ENSP00000336931	Akirin-1; Akirin 1	Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction	0.460
AKIRIN2	AKIRIN1	ENSP00000257787	ENSP00000392678	Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family	Akirin-1; Akirin 1	0.870
AKIRIN2	MANEAL	ENSP00000257787	ENSP00000362136	Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	0.601
AKIRIN2	NT5C1A	ENSP00000257787	ENSP00000235628	Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family	Cytosolic 5’-nucleotidase 1A; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia; 5’-nucleotidases	0.426
AKIRIN2	PNRC1	ENSP00000257787	ENSP00000336931	Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family	Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction	0.446
ANKRD34A	MANEAL	ENSP00000475189	ENSP00000362136	Ankyrin repeat domain-containing protein 34A; Ankyrin repeat domain containing; Belongs to the ANKRD34 family	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	0.525
DISP2	MANEAL	ENSP00000267889	ENSP00000362136	Dispatched RND transporter family member 2	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	0.669
FAM124B	MANEAL	ENSP00000386895	ENSP00000362136	Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	0.553
MANEAL	AKIRIN1	ENSP00000362136	ENSP00000392678	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	Akirin-1; Akirin 1	0.623
MANEAL	AKIRIN2	ENSP00000362136	ENSP00000257787	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family	0.601
MANEAL	ANKRD34A	ENSP00000362136	ENSP00000475189	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	Ankyrin repeat domain-containing protein 34A; Ankyrin repeat domain containing; Belongs to the ANKRD34 family	0.525
MANEAL	DISP2	ENSP00000362136	ENSP00000267889	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	Dispatched RND transporter family member 2	0.669
MANEAL	FAM124B	ENSP00000362136	ENSP00000386895	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family	0.553
MANEAL	NT5C1A	ENSP00000362136	ENSP00000235628	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	Cytosolic 5’-nucleotidase 1A; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia; 5’-nucleotidases	0.561
MANEAL	PNRC1	ENSP00000362136	ENSP00000336931	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction	0.547
MANEAL	RRAGD	ENSP00000362136	ENSP00000358423	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	Ras-related GTP-binding protein D; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids	0.522
MANEAL	ST3GAL4	ENSP00000362136	ENSP00000436047	Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant; Belongs to the glycosyltransferase 29 family	0.548

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