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STRINGSTRING
GDF5 GDF5 MKX MKX MSTN MSTN COL1A1 COL1A1 DCN DCN TNMD TNMD FMOD FMOD SCX SCX KERA KERA BGN BGN GDF7 GDF7
"TNMD" - Tenomodulin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNMDTenomodulin; May be an angiogenesis inhibitor; BRICHOS domain containing (317 aa)    
Predicted Functional Partners:
SCX
Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages; Basic helix-loop-helix proteins (201 aa)
            
  0.911
GDF7
Growth/differentiation factor 7; May play an active role in the motor area of the primate neocortex (450 aa)
      
   
  0.803
MKX
Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion; TALE class homeoboxes and pseudogenes (352 aa)
      
   
  0.784
DCN
Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans (359 aa)
      
   
  0.735
GDF5
Growth/differentiation factor 5; Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upo [...] (501 aa)
            
  0.732
FMOD
Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily (376 aa)
      
   
  0.717
MSTN
Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family (375 aa)
      
   
  0.675
KERA
Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix; Small leucine rich repeat proteoglycans (352 aa)
      
   
  0.642
BGN
Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans (368 aa)
      
   
  0.633
COL1A1
Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Collagens (1464 aa)
      
   
  0.628
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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