| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APMAP | TSPAN6 | ENSP00000217456 | ENSP00000362111 | Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the strictosidine synthase family | Tetraspanin-6; Tetraspanin 6; Tetraspanins | 0.589 |
| FRMPD4 | SEZ6L2 | ENSP00000370057 | ENSP00000481917 | FERM and PDZ domain-containing protein 4; Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate; FERM domain containing | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family | 0.649 |
| FRMPD4 | TSPAN6 | ENSP00000370057 | ENSP00000362111 | FERM and PDZ domain-containing protein 4; Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate; FERM domain containing | Tetraspanin-6; Tetraspanin 6; Tetraspanins | 0.680 |
| GIMAP5 | NDRG1 | ENSP00000477920 | ENSP00000404854 | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regu [...] | 0.540 |
| GIMAP5 | PCGF2 | ENSP00000477920 | ENSP00000482063 | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP | Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5’-GACTNGACT-3’. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to mai [...] | 0.560 |
| GIMAP5 | PNMA1 | ENSP00000477920 | ENSP00000318914 | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP | Paraneoplastic Ma antigens; Belongs to the PNMA family | 0.539 |
| GIMAP5 | TSPAN6 | ENSP00000477920 | ENSP00000362111 | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP | Tetraspanin-6; Tetraspanin 6; Tetraspanins | 0.663 |
| GIMAP5 | ZFHX4 | ENSP00000477920 | ENSP00000430497 | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.600 |
| NDRG1 | GIMAP5 | ENSP00000404854 | ENSP00000477920 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regu [...] | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP | 0.540 |
| NDRG1 | PCGF2 | ENSP00000404854 | ENSP00000482063 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regu [...] | Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5’-GACTNGACT-3’. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to mai [...] | 0.474 |
| NDRG1 | PNMA1 | ENSP00000404854 | ENSP00000318914 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regu [...] | Paraneoplastic Ma antigens; Belongs to the PNMA family | 0.474 |
| NDRG1 | TSG101 | ENSP00000404854 | ENSP00000251968 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regu [...] | Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding [...] | 0.440 |
| NDRG1 | TSPAN6 | ENSP00000404854 | ENSP00000362111 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regu [...] | Tetraspanin-6; Tetraspanin 6; Tetraspanins | 0.556 |
| NDRG1 | ZFHX4 | ENSP00000404854 | ENSP00000430497 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regu [...] | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.474 |
| PCGF2 | GIMAP5 | ENSP00000482063 | ENSP00000477920 | Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5’-GACTNGACT-3’. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to mai [...] | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP | 0.560 |
| PCGF2 | NDRG1 | ENSP00000482063 | ENSP00000404854 | Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5’-GACTNGACT-3’. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to mai [...] | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regu [...] | 0.474 |
| PCGF2 | PNMA1 | ENSP00000482063 | ENSP00000318914 | Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5’-GACTNGACT-3’. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to mai [...] | Paraneoplastic Ma antigens; Belongs to the PNMA family | 0.478 |
| PCGF2 | TSPAN6 | ENSP00000482063 | ENSP00000362111 | Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5’-GACTNGACT-3’. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to mai [...] | Tetraspanin-6; Tetraspanin 6; Tetraspanins | 0.583 |
| PCGF2 | ZFHX4 | ENSP00000482063 | ENSP00000430497 | Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5’-GACTNGACT-3’. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to mai [...] | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.553 |
| PNMA1 | GIMAP5 | ENSP00000318914 | ENSP00000477920 | Paraneoplastic Ma antigens; Belongs to the PNMA family | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP | 0.539 |
