node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKDD1A | ARHGAP27 | ENSP00000325895 | ENSP00000403323 | Ankyrin repeat and death domain containing 1A | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing | 0.645 |
ANKDD1A | CCDC135 | ENSP00000325895 | ENSP00000353942 | Ankyrin repeat and death domain containing 1A | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | 0.750 |
ANKDD1A | FHL3 | ENSP00000325895 | ENSP00000362107 | Ankyrin repeat and death domain containing 1A | Four and a half LIM domains 3 | 0.676 |
ANKDD1A | HMHA1 | ENSP00000325895 | ENSP00000439601 | Ankyrin repeat and death domain containing 1A | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity | 0.683 |
ANKDD1A | TAGAP | ENSP00000325895 | ENSP00000356033 | Ankyrin repeat and death domain containing 1A | T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation | 0.704 |
ARHGAP27 | ANKDD1A | ENSP00000403323 | ENSP00000325895 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing | Ankyrin repeat and death domain containing 1A | 0.645 |
ARHGAP27 | CCDC135 | ENSP00000403323 | ENSP00000353942 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | 0.579 |
ARHGAP27 | FHL3 | ENSP00000403323 | ENSP00000362107 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing | Four and a half LIM domains 3 | 0.580 |
ARHGAP27 | HMHA1 | ENSP00000403323 | ENSP00000439601 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity | 0.467 |
CCAR1 | FHL3 | ENSP00000265872 | ENSP00000362107 | Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apopto [...] | Four and a half LIM domains 3 | 0.697 |
CCDC135 | ANKDD1A | ENSP00000353942 | ENSP00000325895 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Ankyrin repeat and death domain containing 1A | 0.750 |
CCDC135 | ARHGAP27 | ENSP00000353942 | ENSP00000403323 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing | 0.579 |
CCDC135 | FHL3 | ENSP00000353942 | ENSP00000362107 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Four and a half LIM domains 3 | 0.621 |
CCDC135 | HMHA1 | ENSP00000353942 | ENSP00000439601 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity | 0.653 |
CCDC135 | TAGAP | ENSP00000353942 | ENSP00000356033 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation | 0.688 |
FBXO32 | FHL3 | ENSP00000428205 | ENSP00000362107 | F-box only protein 32; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1; F-boxes other | Four and a half LIM domains 3 | 0.581 |
FHL3 | ANKDD1A | ENSP00000362107 | ENSP00000325895 | Four and a half LIM domains 3 | Ankyrin repeat and death domain containing 1A | 0.676 |
FHL3 | ARHGAP27 | ENSP00000362107 | ENSP00000403323 | Four and a half LIM domains 3 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing | 0.580 |
FHL3 | CCAR1 | ENSP00000362107 | ENSP00000265872 | Four and a half LIM domains 3 | Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apopto [...] | 0.697 |
FHL3 | CCDC135 | ENSP00000362107 | ENSP00000353942 | Four and a half LIM domains 3 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | 0.621 |