node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKTIP | FUT11 | ENSP00000378152 | ENSP00000361932 | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade; Ubiquitin conjugating enzymes E2 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | 0.545 |
CHST14 | FUT11 | ENSP00000307297 | ENSP00000361932 | Carbohydrate sulfotransferase 14; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may [...] | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | 0.576 |
FUT1 | FUT11 | ENSP00000312021 | ENSP00000361932 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | 0.742 |
FUT1 | FUT2 | ENSP00000312021 | ENSP00000387498 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway; Belongs to the glycosyltransferase 11 family | 0.811 |
FUT1 | FUT8 | ENSP00000312021 | ENSP00000353910 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans; Belongs to the glycosyltransferase 23 family | 0.688 |
FUT1 | MGAT5 | ENSP00000312021 | ENSP00000386377 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; Catalyzes the addition of N-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides; Belongs to the glycosyltransferase 18 family | 0.457 |
FUT1 | POFUT1 | ENSP00000312021 | ENSP00000364902 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | 0.497 |
FUT1 | POFUT2 | ENSP00000312021 | ENSP00000339613 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and l [...] | 0.548 |
FUT11 | AKTIP | ENSP00000361932 | ENSP00000378152 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade; Ubiquitin conjugating enzymes E2 | 0.545 |
FUT11 | CHST14 | ENSP00000361932 | ENSP00000307297 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | Carbohydrate sulfotransferase 14; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may [...] | 0.576 |
FUT11 | FUT1 | ENSP00000361932 | ENSP00000312021 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | 0.742 |
FUT11 | FUT2 | ENSP00000361932 | ENSP00000387498 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway; Belongs to the glycosyltransferase 11 family | 0.534 |
FUT11 | FUT8 | ENSP00000361932 | ENSP00000353910 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans; Belongs to the glycosyltransferase 23 family | 0.751 |
FUT11 | LRRC9 | ENSP00000361932 | ENSP00000454748 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | Leucine-rich repeat-containing protein 9; Leucine rich repeat containing 9 | 0.645 |
FUT11 | MGAT5 | ENSP00000361932 | ENSP00000386377 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; Catalyzes the addition of N-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides; Belongs to the glycosyltransferase 18 family | 0.661 |
FUT11 | POFUT1 | ENSP00000361932 | ENSP00000364902 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | 0.582 |
FUT11 | POFUT2 | ENSP00000361932 | ENSP00000339613 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and l [...] | 0.727 |
FUT11 | TM2D1 | ENSP00000361932 | ENSP00000475700 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42 | 0.530 |
FUT2 | FUT1 | ENSP00000387498 | ENSP00000312021 | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway; Belongs to the glycosyltransferase 11 family | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway; Blood group antigens | 0.811 |
FUT2 | FUT11 | ENSP00000387498 | ENSP00000361932 | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway; Belongs to the glycosyltransferase 11 family | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases | 0.534 |