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STRINGSTRING
MRPS5 MRPS5 MRPS33 MRPS33 AURKAIP1 AURKAIP1 MRPL14 MRPL14 CHCHD1 CHCHD1 MRPL47 MRPL47 MRPS18B MRPS18B PTCD3 PTCD3 GADD45GIP1 GADD45GIP1 MRPS24 MRPS24 MRPS18C MRPS18C
"CHCHD1" - Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHCHD1Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins (118 aa)    
Predicted Functional Partners:
MRPS33
Mitochondrial ribosomal protein S33; Belongs to the mitochondrion-specific ribosomal protein mS33 family (106 aa)
      
    0.996
AURKAIP1
Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation (199 aa)
      
  0.995
MRPS18C
Mitochondrial ribosomal protein S18C (142 aa)
      
    0.995
MRPL14
39S ribosomal protein L14, mitochondrial; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable); Mitochondrial ribosomal proteins (145 aa)
      
    0.995
MRPS24
Mitochondrial ribosomal protein S24; Belongs to the universal ribosomal protein uS3 family (167 aa)
      
  0.994
PTCD3
Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation (689 aa)
      
  0.994
MRPS18B
Mitochondrial ribosomal protein S18B; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily (258 aa)
      
  0.993
MRPL47
Mitochondrial ribosomal protein L47 (250 aa)
      
  0.993
GADD45GIP1
Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis (222 aa)
      
  0.992
MRPS5
Mitochondrial ribosomal protein S5 (430 aa)
      
  0.991
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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