• Version:
  • 11.0 [archived version]
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ZMAT3 ZMAT3 MYCL MYCL BAI2 BAI2 WIZ WIZ ANKRD18B ANKRD18B RLF RLF TAB2 TAB2 CCNT2 CCNT2 RXFP3 RXFP3 RALA RALA RXFP2 RXFP2
"RLF" - Zinc finger protein Rlf in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RLFZinc finger protein Rlf; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (1914 aa)    
Predicted Functional Partners:
MYCL
Protein L-Myc; MYCL proto-oncogene, bHLH transcription factor; Basic helix-loop-helix proteins (394 aa)
           
  0.750
CCNT2
Cyclin-T2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA. Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediat [...] (730 aa)
     
 
  0.711
TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of ’Lys-63’- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at ’Thr-187’. Involved in heart development; Zinc fingers RANBP2-type (693 aa)
           
  0.613
ANKRD18B
Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing (1011 aa)
     
 
  0.553
BAI2
Adhesion G protein-coupled receptor B2; Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT- signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity) (1584 aa)
           
  0.545
RXFP3
Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation; Relaxin family peptide receptors (469 aa)
       
 
  0.544
WIZ
Protein Wiz; May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity); Zinc fingers C2H2-type (794 aa)
           
  0.530
RALA
Ras-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of th [...] (206 aa)
       
 
  0.516
ZMAT3
Zinc finger matrin-type protein 3; Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus; Zinc fingers matrin-type (289 aa)
           
  0.488
RXFP2
Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (754 aa)
       
 
  0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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