SEMG2 protein (human) - STRING database

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SEMG2

Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa (582 aa)

Predicted Functional Partners:

WFDC12

0.837

KLK3

0.788

WFDC8

0.769

SPINT4

0.731

KLK2

0.703

SLPI

0.608

OR5R1

0.557

ZAN

0.556

WFDC5

0.547

PATE4

0.544

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KLK2	SEMG2	ENSP00000313581	ENSP00000361855	Kallikrein-2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	0.703
KLK3	SEMG2	ENSP00000314151	ENSP00000361855	Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	0.788
KLK3	SLPI	ENSP00000314151	ENSP00000342082	Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...]	0.524
OR5R1	SEMG2	ENSP00000308595	ENSP00000361855	Olfactory receptor 5R1; Odorant receptor; Olfactory receptors, family 5	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	0.557
PATE4	SEMG2	ENSP00000411439	ENSP00000361855	Prostate and testis expressed protein 4; May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility; LY6/PLAUR domain containing	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	0.544
SEMG2	KLK2	ENSP00000361855	ENSP00000313581	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Kallikrein-2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin	0.703
SEMG2	KLK3	ENSP00000361855	ENSP00000314151	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins	0.788
SEMG2	OR5R1	ENSP00000361855	ENSP00000308595	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Olfactory receptor 5R1; Odorant receptor; Olfactory receptors, family 5	0.557
SEMG2	PATE4	ENSP00000361855	ENSP00000411439	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Prostate and testis expressed protein 4; May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility; LY6/PLAUR domain containing	0.544
SEMG2	SLPI	ENSP00000361855	ENSP00000342082	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...]	0.608
SEMG2	SPINT4	ENSP00000361855	ENSP00000279058	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Serine peptidase inhibitor, Kunitz type 4	0.731
SEMG2	WFDC12	ENSP00000361855	ENSP00000361871	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing	0.837
SEMG2	WFDC5	ENSP00000361855	ENSP00000361875	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing	0.547
SEMG2	WFDC8	ENSP00000361855	ENSP00000361735	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	WAP four-disulfide core domain containing	0.769
SEMG2	ZAN	ENSP00000361855	ENSP00000480750	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling	0.556
SLPI	KLK3	ENSP00000342082	ENSP00000314151	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...]	Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins	0.524
SLPI	SEMG2	ENSP00000342082	ENSP00000361855	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...]	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	0.608
SLPI	WFDC8	ENSP00000342082	ENSP00000361735	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for nor [...]	WAP four-disulfide core domain containing	0.442
SPINT4	SEMG2	ENSP00000279058	ENSP00000361855	Serine peptidase inhibitor, Kunitz type 4	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	0.731
SPINT4	WFDC8	ENSP00000279058	ENSP00000361735	Serine peptidase inhibitor, Kunitz type 4	WAP four-disulfide core domain containing	0.825

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