COL9A2 protein (human) - STRING database

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COL9A2

Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans (689 aa)

Predicted Functional Partners:

COL9A1

0.999

COL9A3

0.997

COL2A1

0.966

COL11A1

0.936

COL11A2

0.935

MMP13

0.928

MMP3

0.928

LEPRE1

0.928

BGN

0.925

COL10A1

0.924

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BGN	COL11A1	ENSP00000327336	ENSP00000359114	Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans	Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	0.538
BGN	COL2A1	ENSP00000327336	ENSP00000369889	Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans	Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces	0.684
BGN	COL9A1	ENSP00000327336	ENSP00000349790	Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans	Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans	0.927
BGN	COL9A2	ENSP00000327336	ENSP00000361834	Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans	Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans	0.925
BGN	COL9A3	ENSP00000327336	ENSP00000341640	Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans	Collagen alpha-3(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans	0.925
BGN	MMP13	ENSP00000327336	ENSP00000260302	Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.566
BGN	MMP3	ENSP00000327336	ENSP00000299855	Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family	0.563
COL10A1	COL11A1	ENSP00000327368	ENSP00000359114	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	0.935
COL10A1	COL11A2	ENSP00000327368	ENSP00000363840	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	0.925
COL10A1	COL2A1	ENSP00000327368	ENSP00000369889	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces	0.932
COL10A1	COL9A1	ENSP00000327368	ENSP00000349790	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans	0.925
COL10A1	COL9A2	ENSP00000327368	ENSP00000361834	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans	0.924
COL10A1	COL9A3	ENSP00000327368	ENSP00000341640	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Collagen alpha-3(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans	0.923
COL10A1	LEPRE1	ENSP00000327368	ENSP00000236040	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts	0.900
COL10A1	MMP13	ENSP00000327368	ENSP00000260302	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.745
COL10A1	MMP3	ENSP00000327368	ENSP00000299855	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family	0.443
COL11A1	BGN	ENSP00000359114	ENSP00000327336	Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans	0.538
COL11A1	COL10A1	ENSP00000359114	ENSP00000327368	Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens	0.935
COL11A1	COL11A2	ENSP00000359114	ENSP00000363840	Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	0.907
COL11A1	COL2A1	ENSP00000359114	ENSP00000369889	Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces	0.935

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