| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC39 | CCDC79 | ENSP00000405708 | ENSP00000463762 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | 0.605 |
| CCDC39 | ZFP69 | ENSP00000405708 | ENSP00000361791 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.531 |
| CCDC79 | CCDC39 | ENSP00000463762 | ENSP00000405708 | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | 0.605 |
| CCDC79 | ZFP69 | ENSP00000463762 | ENSP00000361791 | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.525 |
| ILDR2 | SORCS1 | ENSP00000271417 | ENSP00000263054 | Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways | Sortilin related VPS10 domain containing receptor 1; Belongs to the VPS10-related sortilin family. SORCS subfamily | 0.571 |
| ILDR2 | TBC1D1 | ENSP00000271417 | ENSP00000261439 | Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways | TBC1 domain family member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | 0.538 |
| ILDR2 | ZFP69 | ENSP00000271417 | ENSP00000361791 | Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.588 |
| SMAP2 | TMCO2 | ENSP00000361803 | ENSP00000361852 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | Transmembrane and coiled-coil domains 2 | 0.640 |
| SMAP2 | ZDHHC23 | ENSP00000361803 | ENSP00000330485 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane; Zinc fingers DHHC-type | 0.604 |
| SMAP2 | ZFP69 | ENSP00000361803 | ENSP00000361791 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.533 |
| SORCS1 | ILDR2 | ENSP00000263054 | ENSP00000271417 | Sortilin related VPS10 domain containing receptor 1; Belongs to the VPS10-related sortilin family. SORCS subfamily | Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways | 0.571 |
| SORCS1 | ZFP69 | ENSP00000263054 | ENSP00000361791 | Sortilin related VPS10 domain containing receptor 1; Belongs to the VPS10-related sortilin family. SORCS subfamily | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.644 |
| TBC1D1 | ILDR2 | ENSP00000261439 | ENSP00000271417 | TBC1 domain family member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways | 0.538 |
| TBC1D1 | ZFP69 | ENSP00000261439 | ENSP00000361791 | TBC1 domain family member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.665 |
| TMCO2 | SMAP2 | ENSP00000361852 | ENSP00000361803 | Transmembrane and coiled-coil domains 2 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | 0.640 |
| TMCO2 | ZDHHC23 | ENSP00000361852 | ENSP00000330485 | Transmembrane and coiled-coil domains 2 | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane; Zinc fingers DHHC-type | 0.558 |
| TMCO2 | ZFP69 | ENSP00000361852 | ENSP00000361791 | Transmembrane and coiled-coil domains 2 | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.576 |
| TOX4 | ZFP69 | ENSP00000477868 | ENSP00000361791 | TOX high mobility group box family member 4; Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.515 |
| TRIM28 | ZFP69 | ENSP00000253024 | ENSP00000361791 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing | 0.906 |
| ZDHHC23 | SMAP2 | ENSP00000330485 | ENSP00000361803 | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane; Zinc fingers DHHC-type | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | 0.604 |
