node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRINP3 | CCDC17 | ENSP00000356432 | ENSP00000432172 | BMP/retinoic acid-inducible neural-specific protein 3; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development; Belongs to the BRINP family | Coiled-coil domain containing 17 | 0.450 |
BRINP3 | ZNF684 | ENSP00000356432 | ENSP00000361784 | BMP/retinoic acid-inducible neural-specific protein 3; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development; Belongs to the BRINP family | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.546 |
CCDC17 | BRINP3 | ENSP00000432172 | ENSP00000356432 | Coiled-coil domain containing 17 | BMP/retinoic acid-inducible neural-specific protein 3; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development; Belongs to the BRINP family | 0.450 |
CCDC17 | CCDC88B | ENSP00000432172 | ENSP00000349238 | Coiled-coil domain containing 17 | Coiled-coil domain-containing protein 88B; Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering t [...] | 0.523 |
CCDC17 | FAM109A | ENSP00000432172 | ENSP00000354461 | Coiled-coil domain containing 17 | Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Pleckstrin homology domain containing | 0.546 |
CCDC17 | TCF19 | ENSP00000432172 | ENSP00000365433 | Coiled-coil domain containing 17 | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger proteins | 0.439 |
CCDC17 | ZNF365 | ENSP00000432172 | ENSP00000387091 | Coiled-coil domain containing 17 | Protein ZNF365; Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) b [...] | 0.487 |
CCDC17 | ZNF684 | ENSP00000432172 | ENSP00000361784 | Coiled-coil domain containing 17 | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.732 |
CCDC88B | CCDC17 | ENSP00000349238 | ENSP00000432172 | Coiled-coil domain-containing protein 88B; Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering t [...] | Coiled-coil domain containing 17 | 0.523 |
CCDC88B | ZNF684 | ENSP00000349238 | ENSP00000361784 | Coiled-coil domain-containing protein 88B; Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering t [...] | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.593 |
FAM109A | CCDC17 | ENSP00000354461 | ENSP00000432172 | Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Pleckstrin homology domain containing | Coiled-coil domain containing 17 | 0.546 |
FAM109A | ZNF684 | ENSP00000354461 | ENSP00000361784 | Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Pleckstrin homology domain containing | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.558 |
GEMIN8 | LRRC8D | ENSP00000369895 | ENSP00000338887 | Gem-associated protein 8; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | 0.793 |
GEMIN8 | ZNF684 | ENSP00000369895 | ENSP00000361784 | Gem-associated protein 8; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.530 |
LRRC8D | GEMIN8 | ENSP00000338887 | ENSP00000369895 | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | Gem-associated protein 8; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] | 0.793 |
LRRC8D | ZNF684 | ENSP00000338887 | ENSP00000361784 | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.538 |
TCF19 | CCDC17 | ENSP00000365433 | ENSP00000432172 | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger proteins | Coiled-coil domain containing 17 | 0.439 |
TCF19 | ZNF684 | ENSP00000365433 | ENSP00000361784 | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger proteins | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.533 |
TRIM28 | ZNF684 | ENSP00000253024 | ENSP00000361784 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
ZDHHC23 | ZNF684 | ENSP00000330485 | ENSP00000361784 | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane; Zinc fingers DHHC-type | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.496 |