| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKFN1 | RIMS3 | ENSP00000321627 | ENSP00000361769 | Ankyrin repeat and fibronectin type III domain containing 1 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | 0.665 |
| ANKRD40 | RIMS3 | ENSP00000285243 | ENSP00000361769 | Ankyrin repeat domain-containing protein 40; Ankyrin repeat domain containing | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | 0.666 |
| ANKRD40 | SUPT20H | ENSP00000285243 | ENSP00000417510 | Ankyrin repeat domain-containing protein 40; Ankyrin repeat domain containing | SPT20 homolog, SAGA complex component | 0.693 |
| DISP1 | RIMS3 | ENSP00000284476 | ENSP00000361769 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion; Belongs to the dispatched family | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | 0.648 |
| EPHA6 | RIMS3 | ENSP00000374323 | ENSP00000361769 | Ephrin type-A receptor 6; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity) | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | 0.582 |
| FAIM2 | RIMS3 | ENSP00000321951 | ENSP00000361769 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | 0.564 |
| FAIM2 | TMEM151B | ENSP00000321951 | ENSP00000393161 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | Transmembrane protein 151B; Belongs to the TMEM151 family | 0.412 |
| IL1RAPL1 | NLGN3 | ENSP00000368278 | ENSP00000351591 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity); Neuroligins | 0.518 |
| IL1RAPL1 | RIMS3 | ENSP00000368278 | ENSP00000361769 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | 0.562 |
| IL1RAPL1 | SHANK2 | ENSP00000368278 | ENSP00000469689 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | SH3 and multiple ankyrin repeat domains protein 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction; Belongs to the SHANK family | 0.835 |
| NLGN3 | IL1RAPL1 | ENSP00000351591 | ENSP00000368278 | Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity); Neuroligins | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | 0.518 |
| NLGN3 | RIMS3 | ENSP00000351591 | ENSP00000361769 | Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity); Neuroligins | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | 0.605 |
| NLGN3 | SHANK2 | ENSP00000351591 | ENSP00000469689 | Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity); Neuroligins | SH3 and multiple ankyrin repeat domains protein 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction; Belongs to the SHANK family | 0.976 |
| RIMS3 | ANKFN1 | ENSP00000361769 | ENSP00000321627 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | Ankyrin repeat and fibronectin type III domain containing 1 | 0.665 |
| RIMS3 | ANKRD40 | ENSP00000361769 | ENSP00000285243 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | Ankyrin repeat domain-containing protein 40; Ankyrin repeat domain containing | 0.666 |
| RIMS3 | DISP1 | ENSP00000361769 | ENSP00000284476 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion; Belongs to the dispatched family | 0.648 |
| RIMS3 | EPHA6 | ENSP00000361769 | ENSP00000374323 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | Ephrin type-A receptor 6; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity) | 0.582 |
| RIMS3 | FAIM2 | ENSP00000361769 | ENSP00000321951 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | 0.564 |
| RIMS3 | IL1RAPL1 | ENSP00000361769 | ENSP00000368278 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | 0.562 |
| RIMS3 | NLGN3 | ENSP00000361769 | ENSP00000351591 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis | Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity); Neuroligins | 0.605 |
