| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GLRA3 | HMGA1 | ENSP00000274093 | ENSP00000399888 | Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to [...] | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3’-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions; Canonical high mobility group | 0.634 |
| GLRA3 | TCEAL1 | ENSP00000274093 | ENSP00000361708 | Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to [...] | Transcription elongation factor A like family | 0.622 |
| GLRA3 | TCEAL3 | ENSP00000274093 | ENSP00000361711 | Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to [...] | Transcription elongation factor A protein-like 3; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.679 |
| GLRA3 | TCEAL6 | ENSP00000274093 | ENSP00000361860 | Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to [...] | Transcription elongation factor A like family | 0.525 |
| HMGA1 | GLRA3 | ENSP00000399888 | ENSP00000274093 | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3’-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions; Canonical high mobility group | Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to [...] | 0.634 |
| HMGA1 | TCEAL1 | ENSP00000399888 | ENSP00000361708 | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3’-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions; Canonical high mobility group | Transcription elongation factor A like family | 0.642 |
| HMGA1 | TCEAL3 | ENSP00000399888 | ENSP00000361711 | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3’-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions; Canonical high mobility group | Transcription elongation factor A protein-like 3; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.632 |
| NGFRAP1 | TCEAL1 | ENSP00000361728 | ENSP00000361708 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases | Transcription elongation factor A like family | 0.759 |
| NGFRAP1 | TCEAL3 | ENSP00000361728 | ENSP00000361711 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases | Transcription elongation factor A protein-like 3; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.614 |
| NGFRAP1 | TCEAL6 | ENSP00000361728 | ENSP00000361860 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases | Transcription elongation factor A like family | 0.805 |
| NGFRAP1 | TCEAL7 | ENSP00000361728 | ENSP00000329794 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases | Transcription elongation factor A protein-like 7; Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines; Transcription elongation factor A like family | 0.804 |
| TCEA1 | TCEAL1 | ENSP00000428426 | ENSP00000361708 | Transcription elongation factor A protein 1; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3’-terminus; General transcription factors | Transcription elongation factor A like family | 0.641 |
| TCEAL1 | GLRA3 | ENSP00000361708 | ENSP00000274093 | Transcription elongation factor A like family | Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to [...] | 0.622 |
| TCEAL1 | HMGA1 | ENSP00000361708 | ENSP00000399888 | Transcription elongation factor A like family | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3’-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions; Canonical high mobility group | 0.642 |
| TCEAL1 | NGFRAP1 | ENSP00000361708 | ENSP00000361728 | Transcription elongation factor A like family | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases | 0.759 |
| TCEAL1 | TCEA1 | ENSP00000361708 | ENSP00000428426 | Transcription elongation factor A like family | Transcription elongation factor A protein 1; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3’-terminus; General transcription factors | 0.641 |
| TCEAL1 | TCEAL2 | ENSP00000361708 | ENSP00000361866 | Transcription elongation factor A like family | Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.651 |
| TCEAL1 | TCEAL3 | ENSP00000361708 | ENSP00000361711 | Transcription elongation factor A like family | Transcription elongation factor A protein-like 3; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.697 |
| TCEAL1 | TCEAL4 | ENSP00000361708 | ENSP00000361712 | Transcription elongation factor A like family | Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.913 |
| TCEAL1 | TCEAL6 | ENSP00000361708 | ENSP00000361860 | Transcription elongation factor A like family | Transcription elongation factor A like family | 0.901 |
