node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDX4 | FOXJ3 | ENSP00000362613 | ENSP00000361653 | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | 0.521 |
EIF4E3 | FOXJ3 | ENSP00000393324 | ENSP00000361653 | Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity) | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | 0.594 |
FOXJ3 | CDX4 | ENSP00000361653 | ENSP00000362613 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family | 0.521 |
FOXJ3 | EIF4E3 | ENSP00000361653 | ENSP00000393324 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity) | 0.594 |
FOXJ3 | HES5 | ENSP00000361653 | ENSP00000367714 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity); Basic helix-loop-helix proteins | 0.535 |
FOXJ3 | MLXIP | ENSP00000361653 | ENSP00000312834 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | MLX-interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation; Basic helix-loop-helix proteins | 0.519 |
FOXJ3 | POU3F1 | ENSP00000361653 | ENSP00000362103 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis; POU class homeoboxes and pseudogenes | 0.587 |
FOXJ3 | RERE | ENSP00000361653 | ENSP00000338629 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing | 0.531 |
FOXJ3 | RIMKLA | ENSP00000361653 | ENSP00000414330 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | N-acetylaspartylglutamate synthase A; Catalyzes the synthesis of N-acetyl-L-aspartyl-L- glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate; Belongs to the RimK family | 0.563 |
FOXJ3 | SOX6 | ENSP00000361653 | ENSP00000379644 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation; SRY-boxes | 0.637 |
FOXJ3 | ZBTB18 | ENSP00000361653 | ENSP00000351539 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5’- [AC]ACATCTG[GT][AC]-3’ which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...] | 0.696 |
FOXJ3 | ZNF605 | ENSP00000361653 | ENSP00000376135 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | Zinc finger protein 605; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.531 |
HES5 | FOXJ3 | ENSP00000367714 | ENSP00000361653 | Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity); Basic helix-loop-helix proteins | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | 0.535 |
HES5 | SOX6 | ENSP00000367714 | ENSP00000379644 | Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity); Basic helix-loop-helix proteins | Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation; SRY-boxes | 0.560 |
HES5 | ZBTB18 | ENSP00000367714 | ENSP00000351539 | Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity); Basic helix-loop-helix proteins | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5’- [AC]ACATCTG[GT][AC]-3’ which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...] | 0.486 |
MLXIP | FOXJ3 | ENSP00000312834 | ENSP00000361653 | MLX-interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation; Basic helix-loop-helix proteins | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | 0.519 |
MLXIP | RERE | ENSP00000312834 | ENSP00000338629 | MLX-interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation; Basic helix-loop-helix proteins | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing | 0.484 |
POU3F1 | FOXJ3 | ENSP00000362103 | ENSP00000361653 | POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis; POU class homeoboxes and pseudogenes | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | 0.587 |
POU3F1 | RERE | ENSP00000362103 | ENSP00000338629 | POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis; POU class homeoboxes and pseudogenes | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing | 0.462 |
RERE | FOXJ3 | ENSP00000338629 | ENSP00000361653 | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes | 0.531 |