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  • 11.0 [archived version]
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EIF4E3 EIF4E3 RIMKLA RIMKLA HES5 HES5 ZNF605 ZNF605 SOX6 SOX6 FOXJ3 FOXJ3 ZBTB18 ZBTB18 MLXIP MLXIP RERE RERE CDX4 CDX4 POU3F1 POU3F1
"FOXJ3" - Forkhead box protein J3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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FOXJ3Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes (622 aa)    
Predicted Functional Partners:
ZBTB18
Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5’- [AC]ACATCTG[GT][AC]-3’ which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...] (531 aa)
     
 
  0.696
SOX6
Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation; SRY-boxes (808 aa)
       
 
  0.637
EIF4E3
Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity) (224 aa)
       
 
  0.594
POU3F1
POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Thought to be involved in early embryogenesis and neurogenesis; POU class homeoboxes and pseudogenes (451 aa)
           
  0.587
RIMKLA
N-acetylaspartylglutamate synthase A; Catalyzes the synthesis of N-acetyl-L-aspartyl-L- glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate; Belongs to the RimK family (391 aa)
           
  0.563
HES5
Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity); Basic helix-loop-helix proteins (166 aa)
           
  0.535
ZNF605
Zinc finger protein 605; May be involved in transcriptional regulation; Zinc fingers C2H2-type (672 aa)
       
 
  0.531
RERE
Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing (1566 aa)
     
 
  0.531
CDX4
Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family (284 aa)
       
 
  0.521
MLXIP
MLX-interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5’-CACGTG-3’. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation; Basic helix-loop-helix proteins (919 aa)
           
  0.519
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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