node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPZA3 | CRIP3 | ENSP00000326238 | ENSP00000361650 | F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity) | Cysteine rich protein 3; LIM domain containing | 0.558 |
CRIP3 | CAPZA3 | ENSP00000361650 | ENSP00000326238 | Cysteine rich protein 3; LIM domain containing | F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity) | 0.558 |
CRIP3 | FUCA2 | ENSP00000361650 | ENSP00000002165 | Cysteine rich protein 3; LIM domain containing | Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family | 0.553 |
CRIP3 | PSMB11 | ENSP00000361650 | ENSP00000386212 | Cysteine rich protein 3; LIM domain containing | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity); Belongs to the peptidase T1B family | 0.463 |
CRIP3 | SAMM50 | ENSP00000361650 | ENSP00000345445 | Cysteine rich protein 3; LIM domain containing | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex | 0.494 |
CRIP3 | SLC22A15 | ENSP00000361650 | ENSP00000358515 | Cysteine rich protein 3; LIM domain containing | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter; Solute carriers | 0.445 |
CRIP3 | SLC22A31 | ENSP00000361650 | ENSP00000481421 | Cysteine rich protein 3; LIM domain containing | Putative solute carrier family 22 member 31; Organic anion transporter that mediates the uptake of ions; Solute carriers | 0.507 |
CRIP3 | SLC22A7 | ENSP00000361650 | ENSP00000361666 | Cysteine rich protein 3; LIM domain containing | Solute carrier family 22 member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate; Solute carriers | 0.459 |
CRIP3 | TLR10 | ENSP00000361650 | ENSP00000308925 | Cysteine rich protein 3; LIM domain containing | Toll-like receptor 10; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity); Belongs to the Toll-like receptor family | 0.452 |
CRIP3 | TMEM121 | ENSP00000361650 | ENSP00000376304 | Cysteine rich protein 3; LIM domain containing | Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family | 0.510 |
CRIP3 | TTBK1 | ENSP00000361650 | ENSP00000259750 | Cysteine rich protein 3; LIM domain containing | Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family | 0.456 |
FUCA2 | CRIP3 | ENSP00000002165 | ENSP00000361650 | Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family | Cysteine rich protein 3; LIM domain containing | 0.553 |
FUCA2 | SLC22A15 | ENSP00000002165 | ENSP00000358515 | Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter; Solute carriers | 0.487 |
FUCA2 | SLC22A31 | ENSP00000002165 | ENSP00000481421 | Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family | Putative solute carrier family 22 member 31; Organic anion transporter that mediates the uptake of ions; Solute carriers | 0.435 |
PSMB11 | CRIP3 | ENSP00000386212 | ENSP00000361650 | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity); Belongs to the peptidase T1B family | Cysteine rich protein 3; LIM domain containing | 0.463 |
SAMM50 | CRIP3 | ENSP00000345445 | ENSP00000361650 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex | Cysteine rich protein 3; LIM domain containing | 0.494 |
SLC22A15 | CRIP3 | ENSP00000358515 | ENSP00000361650 | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter; Solute carriers | Cysteine rich protein 3; LIM domain containing | 0.445 |
SLC22A15 | FUCA2 | ENSP00000358515 | ENSP00000002165 | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter; Solute carriers | Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family | 0.487 |
SLC22A31 | CRIP3 | ENSP00000481421 | ENSP00000361650 | Putative solute carrier family 22 member 31; Organic anion transporter that mediates the uptake of ions; Solute carriers | Cysteine rich protein 3; LIM domain containing | 0.507 |
SLC22A31 | FUCA2 | ENSP00000481421 | ENSP00000002165 | Putative solute carrier family 22 member 31; Organic anion transporter that mediates the uptake of ions; Solute carriers | Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family | 0.435 |