• Version:
  • 11.0 [archived version]
STRINGSTRING
TSSK1B TSSK1B LYG1 LYG1 SPEF2 SPEF2 UMODL1 UMODL1 ZMYND12 ZMYND12 FBXL5 FBXL5 DYDC1 DYDC1 CACYBP CACYBP SCMH1 SCMH1 IL12RB2 IL12RB2 ZMYND15 ZMYND15
"ZMYND12" - Zinc finger MYND-type containing 12 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZMYND12Zinc finger MYND-type containing 12 (365 aa)    
Predicted Functional Partners:
CACYBP
Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (228 aa)
           
  0.771
UMODL1
Uromodulin like 1 (1446 aa)
     
   
  0.664
ZMYND15
Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-type (750 aa)
     
   
  0.656
SCMH1
Polycomb protein SCMH1; Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes; Belongs to the SCM family (660 aa)
           
  0.654
SPEF2
Sperm flagellar protein 2; Required for correct axoneme development (1822 aa)
           
  0.651
DYDC1
DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis (177 aa)
           
  0.643
LYG1
Lysozyme g-like protein 1; Lysozymes, g-type (194 aa)
           
  0.641
FBXL5
F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued; F-box and leucine rich repeat proteins (691 aa)
           
  0.582
IL12RB2
Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production; Fibronectin type III domain containing (862 aa)
           
  0.453
TSSK1B
Testis-specific serine/threonine-protein kinase 1; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates ’Ser-288’ of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (367 aa)
           
  0.441
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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