node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AES | ZNF503 | ENSP00000221561 | ENSP00000361602 | Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.655 |
ERLIN2 | PROSC | ENSP00000276461 | ENSP00000333551 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | Pyridoxal phosphate homeostasis protein; Pyridoxal 5’-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5’-phosphate (PLP), the active form of vitamin B6 | 0.891 |
ERLIN2 | ZNF503 | ENSP00000276461 | ENSP00000361602 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.702 |
FIGN | TSHZ3 | ENSP00000333836 | ENSP00000240587 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway funct [...] | 0.434 |
FIGN | ZNF503 | ENSP00000333836 | ENSP00000361602 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.686 |
HRASLS | ZNF503 | ENSP00000264735 | ENSP00000361602 | Phospholipid-metabolizing enzyme A-C1; Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs; HRAS like suppressor family | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.585 |
PROSC | ERLIN2 | ENSP00000333551 | ENSP00000276461 | Pyridoxal phosphate homeostasis protein; Pyridoxal 5’-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5’-phosphate (PLP), the active form of vitamin B6 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | 0.891 |
PROSC | ZNF503 | ENSP00000333551 | ENSP00000361602 | Pyridoxal phosphate homeostasis protein; Pyridoxal 5’-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5’-phosphate (PLP), the active form of vitamin B6 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.678 |
SPTSSB | ZNF503 | ENSP00000352097 | ENSP00000361602 | Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.628 |
TEP1 | ZNF503 | ENSP00000262715 | ENSP00000361602 | Telomerase protein component 1; Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity); WD repeat domain containing | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.623 |
TSHZ1 | ZNF503 | ENSP00000323584 | ENSP00000361602 | Teashirt homolog 1; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential); Belongs to the teashirt C2H2-type zinc-finger protein family | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.617 |
TSHZ2 | ZNF503 | ENSP00000360552 | ENSP00000361602 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential); ZF class homeoboxes and pseudogenes | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.555 |
TSHZ3 | FIGN | ENSP00000240587 | ENSP00000333836 | Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway funct [...] | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | 0.434 |
TSHZ3 | ZNF503 | ENSP00000240587 | ENSP00000361602 | Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway funct [...] | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | 0.653 |
ZNF503 | AES | ENSP00000361602 | ENSP00000221561 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development; Belongs to the WD repeat Groucho/TLE family | 0.655 |
ZNF503 | ERLIN2 | ENSP00000361602 | ENSP00000276461 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | 0.702 |
ZNF503 | FIGN | ENSP00000361602 | ENSP00000333836 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | 0.686 |
ZNF503 | HRASLS | ENSP00000361602 | ENSP00000264735 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | Phospholipid-metabolizing enzyme A-C1; Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs; HRAS like suppressor family | 0.585 |
ZNF503 | PROSC | ENSP00000361602 | ENSP00000333551 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | Pyridoxal phosphate homeostasis protein; Pyridoxal 5’-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5’-phosphate (PLP), the active form of vitamin B6 | 0.678 |
ZNF503 | SPTSSB | ENSP00000361602 | ENSP00000352097 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type | Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction | 0.628 |