CCDC23 protein (human) - STRING database

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CCDC23

Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2 (66 aa)

Predicted Functional Partners:

VASH1

0.915

VASH2

0.775

MS4A5

0.714

BCS1L

0.675

SNX22

0.590

ZNF628

0.530

ERMAP

0.493

RUNDC1

0.474

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCS1L	CCDC23	ENSP00000413908	ENSP00000361599	Mitochondrial chaperone BCS1; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex; AAA ATPases	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	0.675
CCDC23	BCS1L	ENSP00000361599	ENSP00000413908	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	Mitochondrial chaperone BCS1; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex; AAA ATPases	0.675
CCDC23	ERMAP	ENSP00000361599	ENSP00000361595	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family	0.493
CCDC23	MS4A5	ENSP00000361599	ENSP00000300190	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	0.714
CCDC23	RUNDC1	ENSP00000361599	ENSP00000354622	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity	0.474
CCDC23	SNX22	ENSP00000361599	ENSP00000323435	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family	0.590
CCDC23	VASH1	ENSP00000361599	ENSP00000167106	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	Vasohibin-1; Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity	0.915
CCDC23	VASH2	ENSP00000361599	ENSP00000428324	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family	0.775
CCDC23	ZNF628	ENSP00000361599	ENSP00000469591	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	Zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity); Zinc fingers C2H2-type	0.530
ERMAP	CCDC23	ENSP00000361595	ENSP00000361599	Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	0.493
ERMAP	MS4A5	ENSP00000361595	ENSP00000300190	Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family	Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	0.523
ERMAP	SNX22	ENSP00000361595	ENSP00000323435	Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family	Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family	0.461
MS4A5	CCDC23	ENSP00000300190	ENSP00000361599	Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	0.714
MS4A5	ERMAP	ENSP00000300190	ENSP00000361595	Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family	0.523
MS4A5	SNX22	ENSP00000300190	ENSP00000323435	Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family	0.673
RUNDC1	CCDC23	ENSP00000354622	ENSP00000361599	RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	0.474
RUNDC1	ZNF628	ENSP00000354622	ENSP00000469591	RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity	Zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity); Zinc fingers C2H2-type	0.697
SNX22	CCDC23	ENSP00000323435	ENSP00000361599	Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family	Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2	0.590
SNX22	ERMAP	ENSP00000323435	ENSP00000361595	Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family	Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family	0.461
SNX22	MS4A5	ENSP00000323435	ENSP00000300190	Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family	Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	0.673

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