node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AQP3 | C1GALT1 | ENSP00000297991 | ENSP00000389176 | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development; Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily | 0.572 |
AQP3 | ERMAP | ENSP00000297991 | ENSP00000361595 | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.582 |
C1GALT1 | AQP3 | ENSP00000389176 | ENSP00000297991 | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development; Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] | 0.572 |
C1GALT1 | ERMAP | ENSP00000389176 | ENSP00000361595 | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development; Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.636 |
ERMAP | AQP3 | ENSP00000361595 | ENSP00000297991 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] | 0.582 |
ERMAP | C1GALT1 | ENSP00000361595 | ENSP00000389176 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development; Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily | 0.636 |
ERMAP | IBTK | ENSP00000361595 | ENSP00000305721 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription; Ankyrin repeat domain containing | 0.526 |
ERMAP | MS4A5 | ENSP00000361595 | ENSP00000300190 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains | 0.523 |
ERMAP | PGM1 | ENSP00000361595 | ENSP00000360124 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family | 0.654 |
ERMAP | PHYHIP | ENSP00000361595 | ENSP00000415491 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system | 0.613 |
ERMAP | PQLC3 | ENSP00000361595 | ENSP00000295083 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | PQ-loop repeat-containing protein 3; PQ loop repeat containing 3 | 0.515 |
ERMAP | TECR | ENSP00000361595 | ENSP00000215567 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Very-long-chain enoyl-CoA reductase; Catalyzes the last of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membran [...] | 0.909 |
ERMAP | TMEM214 | ENSP00000361595 | ENSP00000238788 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress; Belongs to the TMEM214 family | 0.501 |
ERMAP | TPH1 | ENSP00000361595 | ENSP00000250018 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | Tryptophan hydroxylase 1 | 0.545 |
IBTK | ERMAP | ENSP00000305721 | ENSP00000361595 | Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription; Ankyrin repeat domain containing | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.526 |
MS4A5 | ERMAP | ENSP00000300190 | ENSP00000361595 | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.523 |
PGM1 | ERMAP | ENSP00000360124 | ENSP00000361595 | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.654 |
PHYHIP | ERMAP | ENSP00000415491 | ENSP00000361595 | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.613 |
PQLC3 | ERMAP | ENSP00000295083 | ENSP00000361595 | PQ-loop repeat-containing protein 3; PQ loop repeat containing 3 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.515 |
TECR | ERMAP | ENSP00000215567 | ENSP00000361595 | Very-long-chain enoyl-CoA reductase; Catalyzes the last of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membran [...] | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.909 |