| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASCC2 | FAM149A | ENSP00000380877 | ENSP00000227065 | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | Protein FAM149A; Family with sequence similarity 149 member A | 0.446 |
| ASCC2 | ZFYVE21 | ENSP00000380877 | ENSP00000216602 | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type | 0.431 |
| ASCC2 | ZNF691 | ENSP00000380877 | ENSP00000361580 | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.466 |
| FAM149A | ASCC2 | ENSP00000227065 | ENSP00000380877 | Protein FAM149A; Family with sequence similarity 149 member A | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | 0.446 |
| FAM149A | ZFYVE21 | ENSP00000227065 | ENSP00000216602 | Protein FAM149A; Family with sequence similarity 149 member A | Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type | 0.499 |
| FAM149A | ZNF691 | ENSP00000227065 | ENSP00000361580 | Protein FAM149A; Family with sequence similarity 149 member A | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.536 |
| GHRL | ZNF691 | ENSP00000335074 | ENSP00000361580 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation; Endogenous ligands | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.454 |
| MED26 | ZNF691 | ENSP00000263390 | ENSP00000361580 | Mediator of RNA polymerase II transcription subunit 26; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.538 |
| NR1H4 | ZNF691 | ENSP00000447149 | ENSP00000361580 | Bile acid receptor; Isoform 4- Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA; Belongs to the nuclear hormone receptor family. NR1 subfamily | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.495 |
| SLC25A23 | ZNF691 | ENSP00000301454 | ENSP00000361580 | Calcium-binding mitochondrial carrier protein SCaMC-3; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1; EF-hand domain containing | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.580 |
| SLC25A41 | ZNF691 | ENSP00000322649 | ENSP00000361580 | Solute carrier family 25 member 41; Belongs to the mitochondrial carrier (TC 2.A.29) family | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.528 |
| TMEM98 | ZNF691 | ENSP00000463245 | ENSP00000361580 | Transmembrane protein 98 | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.446 |
| TRIM28 | ZNF691 | ENSP00000253024 | ENSP00000361580 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.916 |
| ZFYVE21 | ASCC2 | ENSP00000216602 | ENSP00000380877 | Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | 0.431 |
| ZFYVE21 | FAM149A | ENSP00000216602 | ENSP00000227065 | Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type | Protein FAM149A; Family with sequence similarity 149 member A | 0.499 |
| ZFYVE21 | ZNF691 | ENSP00000216602 | ENSP00000361580 | Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.516 |
| ZNF691 | ASCC2 | ENSP00000361580 | ENSP00000380877 | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation | 0.466 |
| ZNF691 | FAM149A | ENSP00000361580 | ENSP00000227065 | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein FAM149A; Family with sequence similarity 149 member A | 0.536 |
| ZNF691 | GHRL | ENSP00000361580 | ENSP00000335074 | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation; Endogenous ligands | 0.454 |
| ZNF691 | MED26 | ENSP00000361580 | ENSP00000263390 | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Mediator of RNA polymerase II transcription subunit 26; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors | 0.538 |
