| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C10orf11 | CWC25 | ENSP00000361577 | ENSP00000478070 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | 0.847 |
| C10orf11 | DHX38 | ENSP00000361577 | ENSP00000268482 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily | 0.846 |
| C10orf11 | EFTUD2 | ENSP00000361577 | ENSP00000392094 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | 0.846 |
| C10orf11 | RBM25 | ENSP00000361577 | ENSP00000261973 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5’-splice site (5’-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5’-ss usage through the 5’-CGGGCA-3’ RNA sequence. Its association with LUC7 [...] | 0.901 |
| C10orf11 | SF3B1 | ENSP00000361577 | ENSP00000335321 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.848 |
| C10orf11 | SF3B2 | ENSP00000361577 | ENSP00000318861 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.841 |
| C10orf11 | SF3B3 | ENSP00000361577 | ENSP00000305790 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.864 |
| C10orf11 | SNRPD3 | ENSP00000361577 | ENSP00000215829 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Small nuclear ribonucleoprotein Sm D3; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.846 |
| C10orf11 | SNRPF | ENSP00000361577 | ENSP00000266735 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Small nuclear ribonucleoprotein F; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.835 |
| C10orf11 | TXNL4B | ENSP00000361577 | ENSP00000268483 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | Thioredoxin-like protein 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition; Belongs to the DIM1 family | 0.877 |
| CWC25 | C10orf11 | ENSP00000478070 | ENSP00000361577 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | 0.847 |
| CWC25 | DHX38 | ENSP00000478070 | ENSP00000268482 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily | 0.998 |
| CWC25 | EFTUD2 | ENSP00000478070 | ENSP00000392094 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | 0.994 |
| CWC25 | SF3B1 | ENSP00000478070 | ENSP00000335321 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.975 |
| CWC25 | SF3B2 | ENSP00000478070 | ENSP00000318861 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.964 |
| CWC25 | SF3B3 | ENSP00000478070 | ENSP00000305790 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.938 |
| CWC25 | SNRPD3 | ENSP00000478070 | ENSP00000215829 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | Small nuclear ribonucleoprotein Sm D3; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.972 |
| CWC25 | SNRPF | ENSP00000478070 | ENSP00000266735 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | Small nuclear ribonucleoprotein F; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.966 |
| DHX38 | C10orf11 | ENSP00000268482 | ENSP00000361577 | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation | 0.846 |
| DHX38 | CWC25 | ENSP00000268482 | ENSP00000478070 | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | 0.998 |
