| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A1CF | RBM41 | ENSP00000378868 | ENSP00000361557 | APOBEC1 complementation factor; Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay; RNA binding motif containing | RNA-binding protein 41; May bind RNA; RNA binding motif containing | 0.647 |
| A1CF | SRSF9 | ENSP00000378868 | ENSP00000229390 | APOBEC1 complementation factor; Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay; RNA binding motif containing | Serine/arginine-rich splicing factor 9; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10; Belongs to the splicing factor SR family | 0.484 |
| CTPS2 | FAM156A | ENSP00000401264 | ENSP00000482142 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | Protein FAM156A/FAM156B; Family with sequence similarity 156 member A | 0.520 |
| CTPS2 | FAM156B | ENSP00000401264 | ENSP00000469248 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | Family with sequence similarity 156 member B | 0.520 |
| CTPS2 | RBM41 | ENSP00000401264 | ENSP00000361557 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | RNA-binding protein 41; May bind RNA; RNA binding motif containing | 0.667 |
| CTPS2 | TMEM164 | ENSP00000401264 | ENSP00000361143 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | Transmembrane protein 164; Belongs to the TMEM164 family | 0.721 |
| FAM156A | CTPS2 | ENSP00000482142 | ENSP00000401264 | Protein FAM156A/FAM156B; Family with sequence similarity 156 member A | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | 0.520 |
| FAM156A | RBM41 | ENSP00000482142 | ENSP00000361557 | Protein FAM156A/FAM156B; Family with sequence similarity 156 member A | RNA-binding protein 41; May bind RNA; RNA binding motif containing | 0.615 |
| FAM156A | TMEM164 | ENSP00000482142 | ENSP00000361143 | Protein FAM156A/FAM156B; Family with sequence similarity 156 member A | Transmembrane protein 164; Belongs to the TMEM164 family | 0.616 |
| FAM156B | CTPS2 | ENSP00000469248 | ENSP00000401264 | Family with sequence similarity 156 member B | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | 0.520 |
| FAM156B | RBM41 | ENSP00000469248 | ENSP00000361557 | Family with sequence similarity 156 member B | RNA-binding protein 41; May bind RNA; RNA binding motif containing | 0.615 |
| FAM156B | TMEM164 | ENSP00000469248 | ENSP00000361143 | Family with sequence similarity 156 member B | Transmembrane protein 164; Belongs to the TMEM164 family | 0.616 |
| HNRNPC | RBM41 | ENSP00000451291 | ENSP00000361557 | Heterogeneous nuclear ribonucleoproteins C1/C2; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3’-UTR or 5’-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6- methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named ’m(6)A-switch’, f [...] | RNA-binding protein 41; May bind RNA; RNA binding motif containing | 0.718 |
| HNRNPC | SRSF9 | ENSP00000451291 | ENSP00000229390 | Heterogeneous nuclear ribonucleoproteins C1/C2; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3’-UTR or 5’-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6- methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named ’m(6)A-switch’, f [...] | Serine/arginine-rich splicing factor 9; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10; Belongs to the splicing factor SR family | 0.978 |
| HNRNPC | UPF3B | ENSP00000451291 | ENSP00000276201 | Heterogeneous nuclear ribonucleoproteins C1/C2; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3’-UTR or 5’-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6- methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named ’m(6)A-switch’, f [...] | Regulator of nonsense transcripts 3B; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon- [...] | 0.914 |
| NUP62CL | PIH1D3 | ENSP00000361544 | ENSP00000441930 | Nucleoporin-62 C-terminal-like protein; Nucleoporin 62 C-terminal like; Belongs to the nucleoporin NSP1/NUP62 family | Protein PIH1D3; Plays a role in cytoplasmic pre-assembly of axonemal dynein; Belongs to the PIH1 family | 0.723 |
| NUP62CL | RBM41 | ENSP00000361544 | ENSP00000361557 | Nucleoporin-62 C-terminal-like protein; Nucleoporin 62 C-terminal like; Belongs to the nucleoporin NSP1/NUP62 family | RNA-binding protein 41; May bind RNA; RNA binding motif containing | 0.738 |
| PIH1D3 | NUP62CL | ENSP00000441930 | ENSP00000361544 | Protein PIH1D3; Plays a role in cytoplasmic pre-assembly of axonemal dynein; Belongs to the PIH1 family | Nucleoporin-62 C-terminal-like protein; Nucleoporin 62 C-terminal like; Belongs to the nucleoporin NSP1/NUP62 family | 0.723 |
| PIH1D3 | RBM41 | ENSP00000441930 | ENSP00000361557 | Protein PIH1D3; Plays a role in cytoplasmic pre-assembly of axonemal dynein; Belongs to the PIH1 family | RNA-binding protein 41; May bind RNA; RNA binding motif containing | 0.829 |
| RBM41 | A1CF | ENSP00000361557 | ENSP00000378868 | RNA-binding protein 41; May bind RNA; RNA binding motif containing | APOBEC1 complementation factor; Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay; RNA binding motif containing | 0.647 |
