| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C9orf78 | PRRX2 | ENSP00000361524 | ENSP00000361547 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length; Spliceosomal P complex | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | 0.687 |
| DKKL1 | PRRX2 | ENSP00000221498 | ENSP00000361547 | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | 0.568 |
| FOXF2 | PRRX2 | ENSP00000259806 | ENSP00000361547 | Forkhead box protein F2; Probable transcription activator for a number of lung- specific genes; Forkhead boxes | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | 0.568 |
| FOXF2 | TWIST2 | ENSP00000259806 | ENSP00000482581 | Forkhead box protein F2; Probable transcription activator for a number of lung- specific genes; Forkhead boxes | Twist-related protein 2; Binds to the E-box consensus sequence 5’-CANNTG-3’ as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors; Basic helix-loop-helix proteins | 0.509 |
| HOXB13 | PRRX2 | ENSP00000290295 | ENSP00000361547 | Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; HOXL subclass homeoboxes | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | 0.811 |
| METTL11B | PRRX2 | ENSP00000408058 | ENSP00000361547 | Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | 0.564 |
| PAX9 | PRRX2 | ENSP00000355245 | ENSP00000361547 | Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs; Paired boxes | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | 0.731 |
| PRRX2 | C9orf78 | ENSP00000361547 | ENSP00000361524 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length; Spliceosomal P complex | 0.687 |
| PRRX2 | DKKL1 | ENSP00000361547 | ENSP00000221498 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility | 0.568 |
| PRRX2 | FOXF2 | ENSP00000361547 | ENSP00000259806 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Forkhead box protein F2; Probable transcription activator for a number of lung- specific genes; Forkhead boxes | 0.568 |
| PRRX2 | HOXB13 | ENSP00000361547 | ENSP00000290295 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; HOXL subclass homeoboxes | 0.811 |
| PRRX2 | METTL11B | ENSP00000361547 | ENSP00000408058 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation | 0.564 |
| PRRX2 | PAX9 | ENSP00000361547 | ENSP00000355245 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs; Paired boxes | 0.731 |
| PRRX2 | TBX15 | ENSP00000361547 | ENSP00000207157 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | T-box transcription factor TBX15; Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity); T-boxes | 0.624 |
| PRRX2 | TGM6 | ENSP00000361547 | ENSP00000202625 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Protein-glutamine gamma-glutamyltransferase 6; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase family | 0.566 |
| PRRX2 | TMEM9 | ENSP00000361547 | ENSP00000356301 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Transmembrane protein 9; May be involved in intracellular transport | 0.561 |
| PRRX2 | TWIST2 | ENSP00000361547 | ENSP00000482581 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | Twist-related protein 2; Binds to the E-box consensus sequence 5’-CANNTG-3’ as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors; Basic helix-loop-helix proteins | 0.590 |
| TBX15 | PRRX2 | ENSP00000207157 | ENSP00000361547 | T-box transcription factor TBX15; Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity); T-boxes | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | 0.624 |
| TBX15 | TWIST2 | ENSP00000207157 | ENSP00000482581 | T-box transcription factor TBX15; Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity); T-boxes | Twist-related protein 2; Binds to the E-box consensus sequence 5’-CANNTG-3’ as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors; Basic helix-loop-helix proteins | 0.524 |
| TGM6 | PRRX2 | ENSP00000202625 | ENSP00000361547 | Protein-glutamine gamma-glutamyltransferase 6; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase family | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family | 0.566 |
