LRRC73 protein (human) - STRING database

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LRRC73

Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73 (316 aa)

Predicted Functional Partners:

ELFN1

0.577

CEP85

0.519

JPH3

0.512

C17orf51

0.477

ABCG4

0.469

ADPRHL2

0.451

C1orf85

0.450

TMEM208

0.450

NCEH1

0.440

OR4C46

0.430

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG4	LRRC73	ENSP00000481728	ENSP00000361518	ATP-binding cassette sub-family G member 4; May be involved in macrophage lipid homeostasis; ATP binding cassette subfamily G	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	0.469
ADPRHL2	C1orf85	ENSP00000362273	ENSP00000354553	Poly(ADP-ribose) glycohydrolase ARH3; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria	Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family	0.452
ADPRHL2	CEP85	ENSP00000362273	ENSP00000252992	Poly(ADP-ribose) glycohydrolase ARH3; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	0.560
ADPRHL2	LRRC73	ENSP00000362273	ENSP00000361518	Poly(ADP-ribose) glycohydrolase ARH3; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	0.451
ADPRHL2	TMEM208	ENSP00000362273	ENSP00000305892	Poly(ADP-ribose) glycohydrolase ARH3; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria	Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy	0.524
C17orf51	LRRC73	ENSP00000384286	ENSP00000361518	Uncharacterized protein C17orf51; Chromosome 17 open reading frame 51	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	0.477
C17orf51	OR4C46	ENSP00000384286	ENSP00000329056	Uncharacterized protein C17orf51; Chromosome 17 open reading frame 51	Olfactory receptor 4C46; Odorant receptor; Olfactory receptors, family 4	0.570
C1orf85	ADPRHL2	ENSP00000354553	ENSP00000362273	Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family	Poly(ADP-ribose) glycohydrolase ARH3; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria	0.452
C1orf85	CEP85	ENSP00000354553	ENSP00000252992	Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	0.521
C1orf85	LRRC73	ENSP00000354553	ENSP00000361518	Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	0.450
C1orf85	TMEM208	ENSP00000354553	ENSP00000305892	Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family	Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy	0.463
CEP85	ADPRHL2	ENSP00000252992	ENSP00000362273	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Poly(ADP-ribose) glycohydrolase ARH3; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria	0.560
CEP85	C1orf85	ENSP00000252992	ENSP00000354553	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family	0.521
CEP85	LRRC73	ENSP00000252992	ENSP00000361518	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	0.519
CEP85	TMEM208	ENSP00000252992	ENSP00000305892	Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family	Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy	0.576
ELFN1	LRRC73	ENSP00000456548	ENSP00000361518	Protein ELFN1; Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	0.577
JPH3	LRRC73	ENSP00000284262	ENSP00000361518	Junctophilin-3; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	0.512
LRRC73	ABCG4	ENSP00000361518	ENSP00000481728	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	ATP-binding cassette sub-family G member 4; May be involved in macrophage lipid homeostasis; ATP binding cassette subfamily G	0.469
LRRC73	ADPRHL2	ENSP00000361518	ENSP00000362273	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	Poly(ADP-ribose) glycohydrolase ARH3; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria	0.451
LRRC73	C17orf51	ENSP00000361518	ENSP00000384286	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73	Uncharacterized protein C17orf51; Chromosome 17 open reading frame 51	0.477

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