• Version:
  • 11.0 [archived version]
STRINGSTRING
PDX1 PDX1 KATNAL1 KATNAL1 TSC22D2 TSC22D2 STON2 STON2 PCIF1 PCIF1 SLC22A23 SLC22A23 PSAPL1 PSAPL1 ERICH1 ERICH1 FBXO25 FBXO25 PXDC1 PXDC1 RSBN1L RSBN1L
"PCIF1" - Phosphorylated CTD-interacting factor 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PCIF1Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits (704 aa)    
Predicted Functional Partners:
ERICH1
Glutamate-rich protein 1; Glutamate rich 1 (443 aa)
           
  0.684
PXDC1
PX domain containing 1 (231 aa)
           
  0.669
PSAPL1
Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids (521 aa)
           
  0.663
PDX1
Pancreas/duodenum homeobox protein 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5’-[CT]TAAT[TG]-3’. During development [...] (283 aa)
       
 
  0.646
SLC22A23
Solute carrier family 22 member 23 (686 aa)
           
  0.633
RSBN1L
Round spermatid basic protein 1 like (846 aa)
     
   
  0.626
KATNAL1
Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro; Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily (490 aa)
     
   
  0.592
STON2
Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family (920 aa)
           
  0.563
FBXO25
F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity); F-boxes other (367 aa)
     
   
  0.557
TSC22D2
TSC22 domain family member 2 (780 aa)
           
  0.557
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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