• Version:
  • 11.0 [archived version]
STRINGSTRING
C5orf52 C5orf52 C17orf105 C17orf105 DMAP1 DMAP1 CCDC24 CCDC24 FBLL1 FBLL1 RNF220 RNF220 DMRTA1 DMRTA1 SLC6A9 SLC6A9 ERI3 ERI3 B4GALT2 B4GALT2 EIF2B3 EIF2B3
"CCDC24" - Coiled-coil domain containing 24 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
CCDC24Coiled-coil domain containing 24 (307 aa)    
Predicted Functional Partners:
B4GALT2
Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose; Beta 4-glycosyltransferases (401 aa)
           
  0.773
RNF220
E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling; Ring finger proteins (566 aa)
           
  0.753
ERI3
ERI1 exoribonuclease family member 3; Exonucleases (337 aa)
           
  0.738
DMAP1
DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] (467 aa)
           
  0.711
SLC6A9
Sodium- and chloride-dependent glycine transporter 1; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission; Solute carriers (706 aa)
     
   
  0.669
DMRTA1
Doublesex- and mab-3-related transcription factor A1; DMRT like family A1; Belongs to the DMRT family (504 aa)
           
  0.655
C17orf105
Uncharacterized protein C17orf105; Chromosome 17 open reading frame 105 (164 aa)
           
  0.631
C5orf52
Uncharacterized protein C5orf52; Chromosome 5 open reading frame 52 (159 aa)
           
  0.630
EIF2B3
Translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family (452 aa)
           
  0.618
FBLL1
rRNA/tRNA 2’-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2’-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity); Seven-beta-strand methyltransferase motif containing (334 aa)
           
  0.579
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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