| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIF1L | ARHGEF18 | ENSP00000361383 | ENSP00000352995 | Allograft inflammatory factor 1 like; EF-hand domain containing | Rho guanine nucleotide exchange factor 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumfe [...] | 0.478 |
| AIF1L | ASPM | ENSP00000361383 | ENSP00000356379 | Allograft inflammatory factor 1 like; EF-hand domain containing | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | 0.461 |
| AIF1L | ENSG00000268861 | ENSP00000361383 | ENSP00000471635 | Allograft inflammatory factor 1 like; EF-hand domain containing | Uncharacterized protein; Rho guanine nucleotide exchange factor 18 | 0.489 |
| AIF1L | EPB41L4A | ENSP00000361383 | ENSP00000261486 | Allograft inflammatory factor 1 like; EF-hand domain containing | Erythrocyte membrane protein band 4.1 like 4A; FERM domain containing | 0.482 |
| AIF1L | FDXACB1 | ENSP00000361383 | ENSP00000260257 | Allograft inflammatory factor 1 like; EF-hand domain containing | Ferredoxin-fold anticodon-binding domain-containing protein 1; Ferredoxin-fold anticodon binding domain containing 1 | 0.484 |
| AIF1L | MARCKS | ENSP00000361383 | ENSP00000478061 | Allograft inflammatory factor 1 like; EF-hand domain containing | Myristoylated alanine-rich C-kinase substrate; MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein | 0.518 |
| AIF1L | MYH10 | ENSP00000361383 | ENSP00000353590 | Allograft inflammatory factor 1 like; EF-hand domain containing | Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.656 |
| AIF1L | OBSCN | ENSP00000361383 | ENSP00000455507 | Allograft inflammatory factor 1 like; EF-hand domain containing | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing | 0.601 |
| AIF1L | PASK | ENSP00000361383 | ENSP00000351475 | Allograft inflammatory factor 1 like; EF-hand domain containing | PAS domain-containing serine/threonine-protein kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis- regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in [...] | 0.508 |
| AIF1L | SPEG | ENSP00000361383 | ENSP00000311684 | Allograft inflammatory factor 1 like; EF-hand domain containing | Striated muscle preferentially expressed protein kinase; Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells; I-set domain containing | 0.601 |
| ARHGEF18 | AIF1L | ENSP00000352995 | ENSP00000361383 | Rho guanine nucleotide exchange factor 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumfe [...] | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.478 |
| ASPM | AIF1L | ENSP00000356379 | ENSP00000361383 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.461 |
| ENSG00000268861 | AIF1L | ENSP00000471635 | ENSP00000361383 | Uncharacterized protein; Rho guanine nucleotide exchange factor 18 | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.489 |
| EPB41L4A | AIF1L | ENSP00000261486 | ENSP00000361383 | Erythrocyte membrane protein band 4.1 like 4A; FERM domain containing | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.482 |
| FDXACB1 | AIF1L | ENSP00000260257 | ENSP00000361383 | Ferredoxin-fold anticodon-binding domain-containing protein 1; Ferredoxin-fold anticodon binding domain containing 1 | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.484 |
| MARCKS | AIF1L | ENSP00000478061 | ENSP00000361383 | Myristoylated alanine-rich C-kinase substrate; MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.518 |
| MYH10 | AIF1L | ENSP00000353590 | ENSP00000361383 | Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.656 |
| OBSCN | AIF1L | ENSP00000455507 | ENSP00000361383 | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.601 |
| PASK | AIF1L | ENSP00000351475 | ENSP00000361383 | PAS domain-containing serine/threonine-protein kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis- regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in [...] | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.508 |
| SPEG | AIF1L | ENSP00000311684 | ENSP00000361383 | Striated muscle preferentially expressed protein kinase; Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells; I-set domain containing | Allograft inflammatory factor 1 like; EF-hand domain containing | 0.601 |
